166981-79-9

Upstream product

• 626-43-7 3,5-Dichloroaniline 
• 108-56-5 diethyl oxaloacetate 
• 166753-63-5 (Z)-diethyl-3,5-dichloroanilinofumarate 
• 762-21-0 acetylenedicarboxylic acid diethyl ester 
• 166981-77-7 5,7-dichloro-4-benzyloxyquinoline-2-carboxylic acid, ethyl ester 

Downstream Products

• 131123-76-7 5,7-dichlorokynurenic acid 
• 166981-72-2 5,7-Dichloro-4-[benzenesulfonylimino]-1,4-dihydroquinoline-2-carboxylic acid, ethyl ester 
• 5437-27-4 N⁴,N⁴-diethyl-N¹-(5,7-dichloro-[4]quinolyl)-1-methyl-butanediyldiamine 
• 171850-29-6 4-hydroxy-5,7-dichloroquinoline 
• 23834-01-7 4,5,7-trichloroquinoline 

Relevant academic research and scientific papers

Process for preparing 1,4-dihydro-4-oxoquinoline-2-carboxylates and 4-aminoquinoline compounds therefrom

A method for preparing an alkyl 5,7-dihalo-1,4-dihydro-4-oxoquinoline-2-carboxylate ester is described herein. The method comprises cyclizing a compound of Formula III with Eaton's reagent in heated continuous flow reactor to form a compound of Formula IV

METHOD FOR TREATING CHRONIC PAIN

A method for the treatment of chronic pain in a mammal is provided. The method comprises administering to a mammal (e.g., a human) suffering from chronic pain a pain relieving amount of a diarylureido-dihalokynurenate compound. Preferred diarylureido-diha

Heterocyclic benzenesulfonylimine derivatives as inhibitors of IL-1 action

The present invention relates to heterocyclic benzenesulfonylimine derivatives and their use as inhibitors of Interleukin-1 (IL-1) action. Such inhibitors are useful in the treatment of various disease states as disclosed herein including rheumatoid arthr