166985-85-9Relevant academic research and scientific papers
N-Heterocyclic carbene-catalyzed annulation of ynals with amidines: Access to 1,2,6-trisubstituted pyrimidin-4-ones
Xie, Yangxi,Wang, Jian
, p. 4597 - 4600 (2018/05/14)
An N-heterocyclic carbene-catalyzed annulation of ynals and amidines has been reported to construct pyrimidin-4-ones. The protocol features a broad substrate scope and mild conditions. Furthermore, an oxidative strategy to catalytically generate ynal-deri
Synthesis of benzimidazoles by PIDA-promoted direct C(sp2)-H imidation of N-arylamidines
Huang, Jinbo,He, Yimiao,Wang, Yong,Zhu, Qiang
supporting information, p. 13964 - 13967 (2013/01/15)
A metal-free synthesis of diversified benzimidazoles from N-arylamidines through a phenyliodine(III) diacetate (PIDA) promoted intramolecular direct C(sp2)-H imidation has been developed. The reaction proceeds smoothly at 0 °C or ambient temperature to provide the desired products in good to excellent yields. The synthesis of 2-alkyl- or 2-alkyl-fused benzimidazoles, which are generally inaccessible by similar Pd- or Cu-catalyzed approaches, can also be achieved. Copyright
Palladium-catalyzed intramolecular C(sp2)-H amidination by isonitrile insertion provides direct access to 4-aminoquinazolines from N-arylamidines
Wang, Yong,Wang, Honggen,Peng, Jiangling,Zhu, Qiang
supporting information; experimental part, p. 4604 - 4607 (2011/10/12)
An efficient method for the synthesis of 4-amino-2-aryl(alkyl)quinazolines from readily available N-arylamidines and isonitriles via palladium-catalyzed intramolecular aryl C-H amidination by isonitrile insertion has been developed.
N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors
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Page/Page column 47-48, (2008/12/06)
The invention described herein relates to certain pyrimidinedione N-substituted glycine derivatives of formula (I) which are antagonists of HIF prolyl hydroxylases and are useful for treating diseases benefiting from the inhibition of this enzyme, anemia being one example.
