16703-48-3 Usage
Description
2-(Dimethylamino)-2-thioxoacetic acid ethyl ester is a chemical compound characterized by the molecular formula C6H11NO2S. It is an ethyl ester derivative of 2-(dimethylamino)-2-thioxoacetic acid, recognized for its versatility in organic synthesis and chemical research. This white or off-white solid is soluble in organic solvents and is known for its reactivity with a range of nucleophiles and electrophiles, making it a valuable building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It has also been considered as a potential precursor for developing new bioactive compounds, necessitating careful handling and safety precautions due to its potent chemical properties.
Uses
Used in Organic Synthesis:
2-(Dimethylamino)-2-thioxoacetic acid ethyl ester is used as a reagent in organic synthesis for its ability to react with various nucleophiles and electrophiles, facilitating the creation of a wide array of chemical compounds.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, 2-(Dimethylamino)-2-thioxoacetic acid ethyl ester is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Development:
2-(Dimethylamino)-2-thioxoacetic acid ethyl ester is utilized as a building block in the synthesis of agrochemicals, playing a role in the creation of pesticides and other agricultural chemicals to improve crop protection and yield.
Used in the Preparation of Bioactive Compounds:
It is also used as a potential precursor in the preparation of new classes of bioactive compounds, indicating its importance in the discovery and development of novel biologically active substances with potential applications in medicine and other fields.
Check Digit Verification of cas no
The CAS Registry Mumber 16703-48-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,6,7,0 and 3 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 16703-48:
(7*1)+(6*6)+(5*7)+(4*0)+(3*3)+(2*4)+(1*8)=103
103 % 10 = 3
So 16703-48-3 is a valid CAS Registry Number.
16703-48-3Relevant articles and documents
Efficient Synthesis of α-Ketothioamides From α-Nitroketones, Amines or DMF and Elemental Sulfur Under Oxidant-Free Conditions
Zhang, Zhenlei,Yang, Jiusi,Yu, Renjie,Wu, Kairui,Bu, Jiping,Li, Shaoke,Qian, Peng,Sheng, Liangquan
supporting information, p. 5209 - 5212 (2021/10/19)
We have developed a practical, general protocol for denitration of readily available α-nitroketones with sulfur and amines to access a broad range of α-ketothioamides under mild conditions. Such a reaction proceeds under metal-, oxidant-, and catalyst-free conditions to provide synthetically useful α-ketothioamides. Furthermore, the mild reaction conditions tolerate a wide range of substrates especially for the synthesis of aliphatic α-ketothioamides which are rarely reported.
