16703-52-9

Usage

Uses

Used in Organic Synthesis:
ETHYL N,N-DIMETHYLOXAMATE is used as a solvent and reagent for its ability to facilitate various chemical reactions in organic synthesis processes. Its properties make it a valuable component in the creation of a range of organic compounds.
Used as a Protecting Group in Peptide Synthesis:
In the pharmaceutical and biotechnological industries, ETHYL N,N-DIMETHYLOXAMATE is utilized as a protecting group for amines during peptide synthesis. This application is crucial for preventing unwanted side reactions and ensuring the correct formation of peptide bonds.
Used in Production of Other Organic Compounds:
ETHYL N,N-DIMETHYLOXAMATE also serves as a precursor in the synthesis of other organic compounds, contributing to the development of new chemical entities for various applications across different industries.

InChI:InChI=1/C6H11NO3/c1-4-10-6(9)5(8)7(2)3/h4H2,1-3H3

Upstream product

• 124-40-3 dimethyl amine 
• 95-92-1 oxalic acid diethyl ester 
• 64-17-5 ethanol 
• 63017-90-3 N,N-Dimethyl-2,2,2-tris(methylthio)acetamid 
• 1608-14-6 N,N,N'N'-tetramethyl oxamide 
• 4755-77-5 Ethyl oxalyl chloride 
• 17118-74-0 ethyl oxalylchloride 
• 506-59-2 N,N-dimethylammonium chloride 

Downstream Products

• 64-17-5 ethanol 
• 144-62-7 oxalic acid 
• 124-40-3 dimethyl amine 
• 33229-89-9 N,N-dimethylglycine ethyl ester 
• 16703-48-3 ethyl 2-(dimethylamino)-2-thioxoacetate 
• 23206-53-3 N,N-Dimethyl-2-(3-nitro-benzenesulfonylamino)-2-oxo-acetamide 
• 74-85-1 ethene 
• 68-12-2 N,N-dimethyl-formamide 

Relevant academic research and scientific papers

ANTIVIRAL NUCLEOSIDES AND DERIVATIVES THEREOF

Disclosed herein are nucleoside compounds and derivatives thereof, pharmaceutical compositions containing same, and their methods of synthesis. The compounds are useful in treating orthomyxovirus infections, such as influenza infections.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

Substituted heteroaryl compounds and compositions and uses thereof (by machine translation)

The invention discloses substituted heteroaryl compounds and compositions thereof and their use. The compounds of formula (I) compound or type shown in (I) a compound represented by stereo isomers, tautomers, nitrogen oxide, solvate, metabolite, pharmaceutically acceptable salt or its prodrug. The invention also provides a pharmaceutical composition, the compounds and pharmaceutical compositions can be regulated protein kinase, particularly Aurora kinase and JAK kinase activity, for the prevention, treatment, treatment and reduce protein kinase, in particular JAK kinase activity mediated diseases or disorders. (by machine translation)

Synthesis of 2,3-allenylamides utilizing [1,2]-phospha-Brook rearrangement and their application to gold-catalyzed cycloisomerization providing 2-aminofuran derivatives

An efficient synthetic method for 2,3-allenylamides having an oxygen functionality at the 2-position, which are difficult to access by conventional methods, was newly developed by utilizing the [1,2]-phospha-Brook rearrangement under Br?nsted base catalysis. Further manipulation of the 2,3-allenylamides via gold-catalyzed cycloisomerization enables the formation of 2-aminofuran derivatives.

NOVEL ESTERAMIDE COMPOUNDS, METHODS FOR PREPARING SAME, AND USES THEREOF

An esteramide compound of the following formula (I): [in-line-formulae]R1OOC-A-CONR2R3??(I)[/in-line-formulae] is described, wherein: A is a covalent bond or a methylene group —CH2—;R1 is an optionally substituted, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon group including from 5 to 36 carbon atoms,R2 and R3, either identical or different, are groups selected from a hydrogen atom, and optionally substituted hydrocarbon groups, preferably including from 1 to 36 carbon atoms, andR2 and R3 not being simultaneously hydrogen atoms. Also described, are applications for using the esteramide compound, notably as a solvent.

NOVEL USES OF ESTERAMIDE COMPOUNDS

The use of an esteramide compound, alone or as a mixture of the following formula (I): [in-line-formulae]R1OOC-A-CONR2R3??(I)[/in-line-formulae]is described, wherein: A is a covalent bond or a methylene group —CH2—,R1 is an optionally substituted hydrocarbon group having from 1 to 36 carbon atoms,R2 and R3, either identical or different, are groups selected from a hydrogen atom and optionally substituted hydrocarbon groups comprising from 1 to 36 carbon atoms,R2 and R3 may form together a ring having the nitrogen atom to which they are bound, said ring being, if need be, substituted and/or having an additional heteroatom andR2 and R3 not being simultaneously hydrogens. Also described, are applications for using the esteramide compound as a solvent, a co-solvent, a coalescence agent, a crystallization inhibitor, a plasticizer or an agent for increasing biological activity.

PROCESS FOR THE PRODUCTION OF ETHYLENE GLYCOL AND RELATED COMPOUNDS

The present invention provide a process for the production of compounds of general formula (I), Y-CH2CH2-Z (I) wherein Y and Z are functional groups independently selected from the group consisting of a hydroxyl group and R1R2N and wherein R1 and R2 may be the same or different and are functional groups selected from the group consisting of hydrogen and substituted or non- substituited alkyl groups comprising 1 to 8 carbon atoms, or R1R2N is a cyclic compound selected from the group of aromatic and non-aromatic cyclic compounds optionally comprising one or more heteroatoms in addition to the nitrogen atom, said process comprising the steps of: (i) reacting carbon monoxide and an amine in the presence of oxygen to provide a compound of general formula (II) wherein R1 and R2 or R1R2N are as defined above and X is selected from the group consisting of R1R2N and R3O, wherein R3 is selected from alkyl groups comprising 1 to 8 carbon atoms; and (ii) converting the compound of general formula (II) into a compound of general formula (I) by a process that comprises a hydrogenation reaction.

The Preparation and Rearrangements of 5-acyl-2-phenyl-4-substituted 6H-1,3-Thiazines. X-Ray Molecular Structure of 3-Acetyl-2-ethoxycarbonyl-4-(3-oxobutylthio)-5-phenylpyrrole

5-Acyl-2-phenyl-4-substituted 6H-1,3-thiazines are prepared by the reaction of N',N'-substituted N2-thiobenzoylformamidines with methyl vinyl ketone or acrylaldehyde.Rearrangement catalysed by base and subsequent condensation with the acrylic reagent gives substituted pyrrolyl sulphides or substituted 2,6-dihydrothiopyranopyrrole.