167073-06-5

Basic information

• Product Name: (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide
• Synonyms: (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide;N-(trans-2-Fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide;(1R,2S)-2-Fluoro-N-[(1R)-1-phenylethyl]cyclopropanecarboxamide
• CAS NO: 167073-06-5
• Molecular Formula: C13H16FNO
• Molecular Weight: 221.2706432
• Mol File: 167073-06-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 382.7±41.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• PKA: 14.99±0.40(Predicted)
• CAS DataBase Reference: (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide(167073-06-5)
• EPA Substance Registry System: (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide(167073-06-5)

Safety Data

• Hazardous Substances Data: 167073-06-5(Hazardous Substances Data)

Usage

General Description

The chemical (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide is an organic compound with the molecular formula C14H17FN. It is a cyclopropyl amide derivative containing a fluorine atom in the cyclopropyl ring and a phenylethyl group. (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetaMide may have potential applications in medicinal chemistry and drug development due to its unique structure and potential biological activities. Its synthesis and characterization are of interest to researchers in the field of organic chemistry. Further studies are needed to explore its pharmacological properties and potential uses.

Upstream product

• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 167073-07-6 (±)-cis-2-fluorocyclopropanecarboxylic acid 
• 105919-34-4 (+/-)-trans-2-fluorocyclopropanecarboxylic acid 

Downstream Products

• 127199-14-8 (1S,2S)-2-fluorocyclopropane-1-carboxylic acid 
• 127199-13-7 (1R,2R)-(-)-cis-2-fluoro-cyclopropanecarboxylic acid 

Relevant articles and documents

(Fluorocyclopropyl)quinolones. 2. Synthesis and stereochemical structure- activity relationships of chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1- (2-fluorocyclopropyl)quinolone antibacterial agents

A series of novel chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro- 1-(2-fluorocyclopropyl)-quinolones were synthesized as a continuation of a research project of 1-(2-fluorocyclopropyl)-quinolones by considering stereochemical and physicochemical properties of the molecule. Absolute configurations of the 1-(cis-2-fluorocyclopropyl) moiety and the 7-(7-amino- 5-azaspiro-[2.4]heptan-5-yl) moiety were determined by X-ray crystallographic analysis. Stereochemical structure-activity relationship studies indicated that 1-[(1R,2S)-2-fluorocyclopropyl] and 7-[(7S)-amino-5-azaspiro[2.4]heptan- 5-yl] derivatives are more potent against Gram-positive and Gram-negative bacteria than the other stereoisomers and 7-[(7S)-7-amino-5-azaspiro[2.4]- heptan-5-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]quinolone (33) is the most potent of all stereoisomers. Pharmacokinetic profiles and physicochemical properties of the selected compounds were also examined, and it was found that 33 (DU-6859a) possesses moderate lipophilicity and good pharmacokinetic profiles.