167073-06-5 Usage
Uses
Used in Medicinal Chemistry:
(trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetamide is used as a compound of interest in medicinal chemistry for its potential to contribute to the development of new drugs. Its unique structural features may allow it to interact with biological targets in novel ways, offering opportunities for the treatment of various diseases.
Used in Drug Development:
In the pharmaceutical industry, (trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetamide is utilized as a candidate molecule in drug development. The incorporation of a fluorine atom and a phenylethyl group may enhance its pharmacokinetic and pharmacodynamic properties, such as absorption, distribution, metabolism, and excretion, as well as its affinity and selectivity for specific biological targets.
Used in Organic Chemistry Research:
(trans)-2-fluorocyclopropyl)-N-((R)-1-phenylethyl)acetamide serves as a subject of study in organic chemistry research. Its synthesis and characterization provide insights into the reactivity and properties of cyclopropyl amide derivatives, which can inform the design of new synthetic routes and the development of related compounds with tailored properties for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 167073-06-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,6,7,0,7 and 3 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 167073-06:
(8*1)+(7*6)+(6*7)+(5*0)+(4*7)+(3*3)+(2*0)+(1*6)=135
135 % 10 = 5
So 167073-06-5 is a valid CAS Registry Number.
167073-06-5Relevant academic research and scientific papers
(Fluorocyclopropyl)quinolones. 2. Synthesis and stereochemical structure- activity relationships of chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-1- (2-fluorocyclopropyl)quinolone antibacterial agents
Kimura,Atarashi,Kawakami,Sato,Hayakawa
, p. 3344 - 3352 (2007/10/02)
A series of novel chiral 7-(7-amino-5-azaspiro[2.4]heptan-5-yl)-8-chloro- 1-(2-fluorocyclopropyl)-quinolones were synthesized as a continuation of a research project of 1-(2-fluorocyclopropyl)-quinolones by considering stereochemical and physicochemical properties of the molecule. Absolute configurations of the 1-(cis-2-fluorocyclopropyl) moiety and the 7-(7-amino- 5-azaspiro-[2.4]heptan-5-yl) moiety were determined by X-ray crystallographic analysis. Stereochemical structure-activity relationship studies indicated that 1-[(1R,2S)-2-fluorocyclopropyl] and 7-[(7S)-amino-5-azaspiro[2.4]heptan- 5-yl] derivatives are more potent against Gram-positive and Gram-negative bacteria than the other stereoisomers and 7-[(7S)-7-amino-5-azaspiro[2.4]- heptan-5-yl]-8-chloro-1-[(1R,2S)-2-fluorocyclopropyl]quinolone (33) is the most potent of all stereoisomers. Pharmacokinetic profiles and physicochemical properties of the selected compounds were also examined, and it was found that 33 (DU-6859a) possesses moderate lipophilicity and good pharmacokinetic profiles.
