167073-07-6

Basic information

• Product Name: Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2R)-
• Synonyms: Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2R)-;(1S,2R)-2-fluorocyclopropane-1-carboxylic acid
• CAS NO: 167073-07-6
• Molecular Formula: C4H5FO2
• Molecular Weight: 104.0797032
• Mol File: 167073-07-6.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 202.3±33.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 4.00±0.11(Predicted)
• CAS DataBase Reference: Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2R)-(167073-07-6)
• EPA Substance Registry System: Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2R)-(167073-07-6)

Safety Data

• Hazardous Substances Data: 167073-07-6(Hazardous Substances Data)

Usage

General Description

Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2R)- is a chemical compound with a molecular formula of C4H5FO2. It is a derivative of cyclopropanecarboxylic acid, which is a carboxylic acid containing a three-membered cyclopropane ring. The addition of a fluorine atom to the carbon adjacent to the carboxylic acid group adds unique properties to the compound, making it potentially useful in various chemical reactions and processes. Additionally, the (1S,2R) configuration indicates the stereochemistry of the molecule, suggesting the specific orientation of the substituents relative to each other. Cyclopropanecarboxylic acid, 2-fluoro-, (1S,2R)- may have applications in pharmaceutical research, organic synthesis, and other chemical industries.

Upstream product

• 152237-14-4 tert-butyl 2-fluoro-cyclopropane-1-carboxylate 
• 216872-00-3 (1R,2R)-2-Fluoro-cyclopropanecarboxylic acid propyl ester 
• 152237-14-4 trans-t-butyl-2-fluorocyclopropane-1-carboxylate 
• 152237-14-4 cis-t-butyl-2-fluorocyclopropane-1-carboxylate 
• 152237-14-4 tert-butyl cis-2-fluorocyclopropanecarboxylate 
• 154001-42-0 C₄H₅FO₂*C₁₅H₁₇N 
• 216872-25-2 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid hexyl ester 
• 177564-60-2 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid pentyl ester 
• 161582-46-3 (1R,2R)-2-Fluoro-cyclopropanecarboxylic acid butyl ester 
• 161582-46-3 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid butyl ester 
• 177564-59-9 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid propyl ester 
• 177933-51-6 (1S,2S)-2-Fluorocyclopropanecarboxylic Acid Ethyl Ester 
• 188428-48-0 cis-ethyl 2-fluorocyclopropanecarboxylate 
• 127199-12-6 (1S,2S)-2-Fluoro-cyclopropanecarboxylic acid ((R)-1-phenyl-ethyl)-amide 

Downstream Products

• 127199-16-0 tert-butyl N-<(1R,2S)-2-fluorocyclopropyl>carbamate 
• 167073-09-8 tert-butyl N-[(1S,2R)-2-fluorocyclopropyl]carbamate 
• 169884-67-7 (rac-(1R,2S)-2-fluorocyclopropyl)methanol 
• 169884-67-7 (rac-(1R,2R)-2-fluorocyclopropyl)methanol 
• 185225-82-5 cis-2-fluorocyclopropanoyl chloride 
• 169884-67-7 ((1R,2S)-2-fluorocyclopropyl)methanol 
• 169884-67-7 [(1R,2R)-2-fluorocyclopropyl]methanol 
• 185225-82-5 (±)-trans-2-fluorocyclopropanecarbonyl chloride 
• 185225-82-5 (1R,2S)-2-fluorocyclopropane carbonyl chloride 
• 185225-82-5 (±)-cis-2- fluorocyclopropanecarbonyl chloride 

Relevant articles and documents

Novel process for synthesizing 2 -fluorocyclopropylamine with high selectivity and asymmetric synthesis

A novel highly selective asymmetric synthesis process of 2 -fluorocyclopropylamine (Structural I). The method provided by the invention uses 1 - fluorine -1 - benzene (propylene) sulfonyl methane and chiral epichlorohydrin to construct chiral cyclopropane under basic conditions, and a new synthetic route not only achieves a special cis-trans selectivity, but also has a highly specific stereoselectivity. The synthesis route is efficient, the reaction condition is mild, the method is suitable for large industrial production in a green environment, 2 -fluorocyclopropylamine production cost is greatly reduced.

Racemic recovery method of by-product in resolution mother liquor of intermediate of sitafloxacin

The invention discloses a racemic recovery method of the by-product in a resolution mother liquor of an intermediate of sitafloxacin. The method specifically comprises following steps: (1) carrying out resolution on a raceme 2-fluorocyclopropanecarboxylic

Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid

A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopro