167145-50-8

Upstream product

• 206755-80-8 1-(2-benzyloxyphenyl)-4-phenylbutadiene 
• 122-78-1 phenylacetaldehyde 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 
• 14371-10-9 (E)-3-phenylpropenal 
• 54314-85-1 (3-benzyloxypropyl)triphenylphosphonium bromide 
• 33538-83-9 3-(2-methoxyphenyl)propanal 
• 3360-41-6 4-phenyl-butan-1-ol 
• 108-95-2 phenol 
• 104-53-0 3-phenyl-propionaldehyde 
• 108-94-1 cyclohexanone 

Downstream Products

• 167142-74-7 4-t-butoxycarbonyl-2-[2-(4-phenylbutyl)phenoxymethyl]morpholine 
• 167145-62-2 2-[2-(4-phenylbutyl)phenoxymethyl]oxirane 
• 167143-18-2 1-t-Butoxycarbonyl-2-{2-[2-(4-phenylbutyl)-phenoxy]ethyl}piperidine 
• 167145-68-8 (4R)-4-Benzyloxy-1-t-butoxycarbonyl-2-[2-(4-phenylbutyl) phenoxymethyl]pyrrolidine 
• 167142-62-3 3-dimethylamino-1-[2-(4-phenylbutyl)phenoxy]-2-propanol 
• 206755-85-3 1-tert-butoxycarbonyl-3-[2-(4-phenylbutyl)phenoxymethyl]piperidine 

Relevant academic research and scientific papers

Palladium-catalyzed aerobic synthesis of: Ortho -substituted phenols from cyclohexanones and primary alcohols

Due to the importance of phenols as structural cores and precursors of chemical products, synthesis of site-specific substituted phenols is highly desirable and a significant challenge. An aerobic palladium-catalyzed site-specific synthesis of ortho-substituted phenols from cyclohexanones and primary alcohols via an oxidation/aldol/dehydration/aromatization process has been developed. Various substituted cyclohexanones and primary alcohols are successfully transformed into ortho-substituted phenols. In addition, this catalytic reaction uses air as the terminal oxidant and generates water as the sole by-product. Furthermore, the method can also be extended to polyhydroxyl substituted substrates with high chemoselectivity between primary and secondary alcohols. This method provides a greener tool for synthesizing primary alkyl ortho-substituted phenols.

Dearomatization-Rearomatization Strategy for ortho-Selective Alkylation of Phenols with Primary Alcohols

Phenols are common precursors and core structures of a variety of industrial chemicals ranging from pharmaceuticals to polymers. However, the synthesis of site-specifically substituted phenols is challenging, and thus the development of new methods for this purpose would be highly desirable. Reported here is a protocol for palladium-catalyzed ortho-selective alkylation reactions of phenols with primary alcohols by a dearomatization-rearomatization strategy, with water as the sole by-product. Various substituted phenols and primary alcohols were compatible with the standard reaction conditions. The detailed mechanism of this transformation was also investigated.

[2-ω-phenylalkyl)phenoxy]alkylamines: Synthesis and dual dopamine2 (D2) and 5-hydroxytryptamine2 (5-HT2) receptor antagonistic activities

A series of [2-(ω-phenylalkyl)phenoxy]alkylamines was synthesized and their 5-hydroxytryptamine2 (5-HT2) and/or dopamine2 (D2) receptor antagonistic activities were examined in vitro. [2-(4- Phenylbutyl)phenoxy]

ALPHA-OMEGA-DIARYLALKANE COMPOUNDS SEROTONIN-2 RECEPTOR AGONISTS

Compounds of formula (I): STR1 [wherein: R 1 is aryl; R 2 is hydrogen, alkyl, alkoxy, halogen or cyano; R 3 is a group of formula--B--NR 4 R 5, where R 4 and R 5 are independently hydrogen, alkyl or substituted alkyl or R 4 and R 5, together with the nitr