167159-52-6

Upstream product

• 28750-77-8 α-chloro-3,4-dimetoxybenzeneacetonitrile 
• 54512-75-3 1-bromo-5-chloropentane 
• 106-45-6 para-thiocresol 
• 113053-02-4 3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile 
• 167159-49-1 α-(5-iodopentyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile 
• 64-17-5 ethanol 
• 167158-91-0 α-(3,4-dimethoxyphenyl)-1,3-dihydro-α-<(4-methylphenyl)thio>-1,3-dioxo-2H-isoindole-2-heptanenitrile 
• 167159-64-0 α-(5-chloropentyl)-3,4-dimethoxy-α-[(4-methylphenyl)thio]benzeneacetonitrile 

Relevant academic research and scientific papers

Novel multidrug resistance reversal agents

A series of 59 α-aryl-α-thioether-alkyl, -alkanenitrile, and - alkanecarboxylic acid methyl ester tetrahydroisoquinoline and isoindoline derivatives (15a-48) were synthesized and evaluated as multidrug resistance (MDR) reversal agents. The compounds were

MDR reversal agents

Compounds of the general formula: STR1 wherein R1, R2, R3, R4 and R5 are herein described, A is a straight or branched (C2 -C12)alkyl or a phenyl moiety and B is a moiety of the formula: STR2 The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.