16717-25-2

Usage

Uses

Used in Pharmaceutical Industry:
6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE is used as a building block for the synthesis of various biologically active molecules, contributing to the development of novel drugs. Its unique structure allows for the creation of pharmaceutical intermediates that can be further modified to enhance their therapeutic properties.
Used in Medicinal Chemistry Research:
In the realm of medicinal chemistry, 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE serves as a valuable research tool. It is utilized to explore the structure-activity relationships of quinoline-based compounds, aiding in the discovery of new drug candidates with improved efficacy and selectivity.
Used in Drug Development:
As a synthetic intermediate, 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE is instrumental in the development of innovative drugs. Its potential applications in the pharmaceutical industry are currently under investigation, with the aim of identifying its therapeutic potential and optimizing its use in various medical conditions.

Upstream product

• 5332-25-2 6-bromoquinoline 
• 22190-35-8 6-bromo-1,2,3,4-tetrahydroquinoline 
• 606-43-9 1-methyl-2-quinolin-2(1H)-one 

Downstream Products

• 77514-31-9 2,6-di-bromoquinoline 
• 1439401-76-9 6-bromo-1-methyl-3-phenylquinolin-2(1H)-one 

Relevant academic research and scientific papers

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

Combining Eosin y with Selectfluor: A Regioselective Brominating System for Para-Bromination of Aniline Derivatives

A mild, metal-free, and absolutely para-selective bromination of aniline derivatives has been developed in excellent yields, wherein the organic dye Eosin Y is employed as the bromine source in company with Selectfluor. Neither air nor moisture sensitive, this facile reaction proceeds smoothly at room temperature and completes within a short time. Mechanistic studies indicate a radical pathway; therefore, the existence of an in situ generated brominating reagent, "Selectbrom", is postulated, which may reasonably account for the unique regioselectivity for the para-bromination of N-acyl- as well as N-sulfonylanilines.

HETEROCYCLIC BIARYL DERIVATIVE AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT

Novel heterocyclic biaryl derivatives were disclosed which are useful as pharmaceutical agents and which exhibit a phosphodiesterase-inhibitory action. The heterocyclic biaryl derivatives are represented by the following general formula (1): wherein the H