16717-25-2

Basic information

• Product Name: 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE
• Synonyms: 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE;6-BROMO-1-METHYL-1H-QUINOLIN-2-ONE;6-Bromo-1-methyl-2(1H)-quinolinone;6-Bromo-1-methylcarbostyril
• CAS NO: 16717-25-2
• Molecular Formula: C₁₀H₈BrNO
• Molecular Weight: 238.083
• Mol File: 16717-25-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 144-146℃
• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE(16717-25-2)
• EPA Substance Registry System: 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE(16717-25-2)

Safety Data

• Hazardous Substances Data: 16717-25-2(Hazardous Substances Data)

Usage

General Description

6-Bromo-1-methylquinolin-2(1H)-one is a chemical compound with the molecular formula C10H8BrNO. It is a derivative of quinolinone and possesses a bromine atom at the 6th position and a methyl group at the 1st position of the quinoline ring. 6-BROMO-1-METHYLQUINOLIN-2(1H)-ONE has been studied for its potential pharmaceutical applications, particularly in the field of medicinal chemistry. It is known for its use as a building block in the synthesis of various biologically active molecules and pharmaceutical intermediates, and it has potential as a synthetic intermediate for the development of novel drugs. However, further research is needed to fully understand its therapeutic potential and possible applications in the pharmaceutical industry.

Upstream product

• 606-43-9 1-methyl-2-quinolin-2(1H)-one 
• 22190-35-8 6-bromo-1,2,3,4-tetrahydroquinoline 
• 5332-25-2 6-bromoquinoline 

Downstream Products

• 1439401-76-9 6-bromo-1-methyl-3-phenylquinolin-2(1H)-one 
• 77514-31-9 2,6-di-bromoquinoline 

Relevant articles and documents

Covalent Organic Frameworks toward Diverse Photocatalytic Aerobic Oxidations

Photoactive two-dimensional covalent organic frameworks (2D-COFs) have become promising heterogenous photocatalysts in visible-light-driven organic transformations. Herein, a visible-light-driven selective aerobic oxidation of various small organic molecules by using 2D-COFs as the photocatalyst was developed. In this protocol, due to the remarkable photocatalytic capability of hydrazone-based 2D-COF-1 on molecular oxygen activation, a wide range of amides, quinolones, heterocyclic compounds, and sulfoxides were obtained with high efficiency and excellent functional group tolerance under very mild reaction conditions. Furthermore, benefiting from the inherent advantage of heterogenous photocatalysis, prominent sustainability and easy photocatalyst recyclability, a drug molecule (modafinil) and an oxidized mustard gas simulant (2-chloroethyl ethyl sulfoxide) were selectively and easily obtained in scale-up reactions. Mechanistic investigations were conducted using radical quenching experiments and in situ ESR spectroscopy, all corroborating the proposed role of 2D-COF-1 in photocatalytic cycle.

HETEROCYCLIC BIARYL DERIVATIVE AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT

Novel heterocyclic biaryl derivatives were disclosed which are useful as pharmaceutical agents and which exhibit a phosphodiesterase-inhibitory action. The heterocyclic biaryl derivatives are represented by the following general formula (1): wherein the H