1672-88-4

Basic information

• Product Name: Furazidine
• Synonyms: furazidine;FURAGIN;FURAZIDIN(FURAGIN) ,99%;FURAZIDIN (FURAGIN);1-[[(E)-3-(5-Nitrofuran-2-yl)prop-2-enylidene]amino]imidazolidine-2,4-dione;1-(N-[1-Methyl-2-(5-nitropyr-2-yl)-ethyliden]amino]imidazolidine-2,4-dione;1-[[3-(5-Nitro-2-furanyl)-2-propenylidene]amino]-2,4-imidazolidinedione;NF-416
• CAS NO: 1672-88-4
• Molecular Formula: C₁₀H₈N₄O₅
• Molecular Weight: 264.19
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1672-88-4.mol

Chemical Properties

• Melting Point: 267-270°C (dec.)
• Appearance: /
• Density: 1.61 g/cm³
• Refractive Index: 1.689
• Storage Temp.: Refrigerator
• PKA: 7.79±0.10(Predicted)
• CAS DataBase Reference: Furazidine(CAS DataBase Reference)
• NIST Chemistry Reference: Furazidine(1672-88-4)
• EPA Substance Registry System: Furazidine(1672-88-4)

Safety Data

• Hazardous Substances Data: 1672-88-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Furazidine is used as an antibiotic for the treatment of urinary tract infections. It demonstrates similar efficacy to Ciprofloxacin in treating acute cystitis, although the duration of therapy is longer. The antibiotic properties of Furazidine make it a valuable compound in the pharmaceutical industry for combating bacterial infections.
Used in Antimicrobial Applications:
As a nitrofuran antibiotic, Furazidine is employed in various antimicrobial applications to combat bacterial infections, particularly those affecting the urinary tract. Its effectiveness in treating such infections highlights its importance in the field of medicine and healthcare.

InChI:InChI=1/C10H8N4O5/c15-8-6-13(10(16)12-8)11-5-1-2-7-3-4-9(19-7)14(17)18/h1-5H,6H2,(H,12,15,16)/b2-1+,11-5+

Upstream product

• 6301-02-6 1-aminohydantoin 
• 52661-56-0 5-nitrofurylacrolein 
• 1874-22-2 3-(5-nitrofuran-2-yl)-2-propenal 

Relevant articles and documents

Synthesis method of 1-((3-(5-nitro-2-furyl)allylidene)amino) hydantoin

The invention discloses a synthesis method of 1-((3-(5-nitro-2-furyl)allylidene)amino) hydantoin. The synthesis method is characterized by including: taking 5-nitrofuranacrolein and propyl aminohydantoin as main raw materials, allowing one-step condensation reaction to prepare a target compound crude product, and refining and purifying N, N-dimethylformamide to obtain 1-((3-(5-nitro-2-furyl)allylidene)amino) hydantoin, wherein a chemical reaction formula is shown as follows. Compared with reported methods, the synthesis method has the advantages that reaction path is short, process is simple and convenient, the raw materials are easy to get, generation of a pollution byproduct-aldehyde during synthesis is avoided, and the method is high in yield, low in cost, few in three wastes and environment-friendly, and reaction conversion rate reaches 98%.

POLYMORPHIC FORMS OF FURAZIDIN

The invention relates to the crystalline forms of Furazidin (1-{[(1E,2E)-3-(5-nitrofuran-2-yl)prop-2-ene-1-ylidene]amino}imidazolidin-2,4-dione) and methods of preparation thereof