16723-58-3Relevant academic research and scientific papers
Unexpected pyrolytic behaviour of substituted benzo[c]thiopyran and thieno[2,3-c]thiopyran s,s-dioxides
Aitken, R. Alan,Hauduc, Clemence,Hossain, M. Selim,McHale, Emily,Schwan, Adrian L.,Slawin, Alexandra M. Z.,Stewart, Colin A.
, p. 1288 - 1295 (2014/11/07)
Flash vacuum pyrolysis (FVP) of benzo[c]thiopyran S,S-dioxide (1) results in formation of indene and 2-vinylbenzaldehyde as previously described. A range of eight analogues with various substitution patterns are found to behave differently. In general, there is no extrusion of SO2 to give products analogous to indene, but unsaturated carbonyl products analogous to 2-vinylbenzaldehyde are formed in most cases by way of ring expansion to a 7-membered ring sultine, extrusion of SO, and intramolecular hydrogen atom transfer. Other processes observed include formation of anthracene via an isomeric 7-membered sultine with loss of SO, CO and methane or butane, and formation of 4-ethylidene-4,5- dihydrocyclobuta[b]thiophenes by way of SO loss, a radical rearrangement, and extrusion of acetone. The analogues with a halogen substituent at position 8 on the benzene ring require a higher temperature to react and give naphthalene resulting from net elimination of HX and SO2. The X-ray crystal structure of 1 is also reported.
A novel synthesis and transformations of isothiochroman 2,2-dioxide
Shyshkina, Olena O.,Tkachuk, Tetyana M.,Volovnenko, Tetiana A.,Volovenko, Yulian M.,Zubatyuk, Roman I.,Medviediev, Volodymyr V.,Shishkin, Oleg V.
, p. 4296 - 4299 (2012/09/25)
A convenient synthesis of isothiochromen-4-one 2,2-dioxide was carried out via cyclisation of o-cyanobenzyl thioacetate by a Thorpe reaction. The reactions of isothiochromen-4-one 2,2-dioxide with nitrogen-containing nucleophilic reagents have been investigated.
METHODS OF TREATMENT OF AMYLOIDOSIS USING BI-CYCLIC ASPARTYL PROTEASE INHIBITORS
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Page/Page column 193, (2010/02/14)
The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
Cycloaromatization and DNA Cleavage of Novel Enyne-allene Systems
Toshima, Kazunobu,Ohta, Kazumi,Ohtsuka, Atsuo,Matsumura, Shuichi,Nakata, Masaya
, p. 1406 - 1407 (2007/10/02)
The novel enyne-allene sulfones 5-8 were prepared by m-chloroperbenzoic acid oxidation of the corresponding enediyne sulfides 1-4; the enyne-allene sulfones 6-8 having a leaving group at the allylic position were aromatized by 1,8-diazabicycloundec
α-Oxosulfines: reactions with alkenes and alkynes
Still, Ian W. J.,Wilson, Donna Kaye T.
, p. 964 - 973 (2007/10/02)
Thiochroman-4-one 1,1-dioxide has been successfully converted into 3-sulfinylthiochroman-4-one 1,1-dioxide and the reactions of this α-oxosulfine with a series of alkenes have been carefully investigated.The α-oxosulfine was found to react as a Diels-Alde
