167256-05-5

Basic information

• Product Name: METHYL (1S,2S)-1-(1,3-BENZODIOXOL-5-YL)-3-(2-HYDROXY-4-METHOXYPHENYL)-5-PROPOXYINDANE-2-CARBOXYLATE
• Synonyms: METHYL (1S,2S)-1-(1,3-BENZODIOXOL-5-YL)-3-(2-HYDROXY-4-METHOXYPHENYL)-5-PROPOXYINDANE-2-CARBOXYLATE
• CAS NO: 167256-05-5
• Molecular Formula: C₂₈H₂₈O₇
• Molecular Weight: 476.52
• Mol File: 167256-05-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: METHYL (1S,2S)-1-(1,3-BENZODIOXOL-5-YL)-3-(2-HYDROXY-4-METHOXYPHENYL)-5-PROPOXYINDANE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL (1S,2S)-1-(1,3-BENZODIOXOL-5-YL)-3-(2-HYDROXY-4-METHOXYPHENYL)-5-PROPOXYINDANE-2-CARBOXYLATE(167256-05-5)
• EPA Substance Registry System: METHYL (1S,2S)-1-(1,3-BENZODIOXOL-5-YL)-3-(2-HYDROXY-4-METHOXYPHENYL)-5-PROPOXYINDANE-2-CARBOXYLATE(167256-05-5)

Safety Data

• Hazardous Substances Data: 167256-05-5(Hazardous Substances Data)

Upstream product

• 190969-65-4 (S)-3-(1,3-benzodioxol-5-yl)-6-propoxy-1H-inden-1-ol 
• 190969-66-5 (S)-3-(1,3-benzodioxol-5-yl)-2,3-dihydro-6-propoxy-1H-indan-1-one 
• 190969-67-6 (S)-Methyl-1-(1,3-benzodioxol-5-yl)-3-[(fluorosulfonyl)oxy]5-propoxy-1H-indene-2-carboxylate 
• 190969-64-3 (E)-3-Benzo[1,3]dioxol-5-yl-1-(2-bromo-5-propoxy-phenyl)-propenone 
• 174527-88-9 3-(1,3-benzodioxol-5-yl)-6-propoxy-1H-inden-1-one 
• 190969-63-2 1-(2-Bromo-5-propoxyphenyl)ethanone 
• 120-57-0 piperonal 
• 191106-49-7 (S)-1-Benzo[1,3]dioxol-5-yl-3-(2-benzyloxy-4-methoxy-phenyl)-5-propoxy-1H-indene-2-carboxylic acid methyl ester 

Downstream Products

• 190965-53-8 [1S-(1α,2α,3α)]-methyl 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-1H-indene-2-carboxylate 
• 167256-08-8 enrasentan 
• 157659-79-5 (+)-(1S,2R,3S)-1-(3,4-methylenedioxyphenyl)-3-[2-(carboxymethoxy)-4-methoxyphenyl]-2,3-dihydro-5-(prop-1-yloxy)-1H-indene-2-carboxylic acid 
• 190965-48-1 (1S,2S,3S)-1-Benzo[1,3]dioxol-5-yl-3-(4-methoxy-2-methoxycarbonylmethoxy-phenyl)-5-propoxy-indan-2-carboxylic acid methyl ester 

Relevant articles and documents

Stereoselective synthesis of endothelin receptor antagonists

PCT No. PCT/US96/18084 Sec. 371 Date May 8, 1998 Sec. 102(e) Date May 8, 1998 PCT Filed Nov. 8, 1996 PCT Pub. No. WO97/17071 PCT Pub. Date May 15, 1997The present invention is directed to a synthetic route for preparing endothelium receptor antagonists of formulae (7B) and (7A) and to the chiral intermediates

Endothelin receptor antagonists

Novel indane and indene derivatives are described which are endothelin receptor antagonists.

A catalytic enantioselective synthesis of the endothelin receptor antagonists SB-209670 and SB-217242. A base-catalyzed stereospecific formal 1,3-hydrogen transfer of a chiral 3-arylindenol

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