190965-53-8

Basic information

• Product Name: [1S-(1α,2α,3α)]-methyl 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-1H-indene-2-carboxylate
• Synonyms: [1S-(1α,2α,3α)]-methyl 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-1H-indene-2-carboxylate
• CAS NO: 190965-53-8
• Molecular Weight: 520.579
• Mol File: 190965-53-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [1S-(1α,2α,3α)]-methyl 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-1H-indene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: [1S-(1α,2α,3α)]-methyl 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-1H-indene-2-carboxylate(190965-53-8)
• EPA Substance Registry System: [1S-(1α,2α,3α)]-methyl 1-(1,3-benzodioxol-5-yl)-2,3-dihydro-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-1H-indene-2-carboxylate(190965-53-8)

Safety Data

• Hazardous Substances Data: 190965-53-8(Hazardous Substances Data)

Upstream product

• 7732-18-5 water 
• 190969-65-4 (S)-3-(1,3-benzodioxol-5-yl)-6-propoxy-1H-inden-1-ol 
• 190969-66-5 (S)-3-(1,3-benzodioxol-5-yl)-2,3-dihydro-6-propoxy-1H-indan-1-one 
• 190969-67-6 (S)-Methyl-1-(1,3-benzodioxol-5-yl)-3-[(fluorosulfonyl)oxy]5-propoxy-1H-indene-2-carboxylate 
• 190969-64-3 (E)-3-Benzo[1,3]dioxol-5-yl-1-(2-bromo-5-propoxy-phenyl)-propenone 
• 174527-88-9 3-(1,3-benzodioxol-5-yl)-6-propoxy-1H-inden-1-one 
• 190969-63-2 1-(2-Bromo-5-propoxyphenyl)ethanone 
• 120-57-0 piperonal 
• 96-49-1 [1,3]-dioxolan-2-one 
• 167256-05-5 (+)Methyl-(1S,2S,3S)-3-(2-Hydroxy-4-methoxyphenyl)-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylate 
• 191106-49-7 (S)-1-Benzo[1,3]dioxol-5-yl-3-(2-benzyloxy-4-methoxy-phenyl)-5-propoxy-1H-indene-2-carboxylic acid methyl ester 

Downstream Products

• 167256-08-8 (1S,2R,3S)-3-[2-(2-Hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid 
• 167256-08-8 enrasentan 

Relevant articles and documents

3-phenyl-1-methylenedioxyphenyl-indane-2-carboxylic acid derivatives

PCT No. PCT/US96/18465 Sec. 371 Date Feb. 4, 1997 Sec. 102(e) Date Feb. 4, 1997 PCT Filed Nov. 8, 1996 PCT Pub. No. WO97/17341 PCT Pub. Date May 15, 1997Invented is an improved process for preparing aromatic ring-fused cyclopentane derivatives. Preferred compounds prepared by this invention are indane carboxylates and cyclopentanopyridine derivatives. The most preferred compounds prepared by this invention are (+)(1S,2R,3S)-3-[2-(2-hydroxyeth-1-yloxy)-4-methoxyphenyl]-1-(3,4-methylenedioxyphenyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof and (+)(1S,2R,3S)-3-(2-carboxymethoxy-4-methoxyphenyl)-1-(3,4-methylenedioxypheyl)-5-(prop-1-yloxy)indane-2-carboxylic acid and pharmaceutically acceptable salts thereof. Also invented are novel intermediates useful in preparing these compounds.