6175-26-4

Upstream product

• 67-56-1 methanol 
• 16728-92-0 N-benzyl-N,N-bis(cyanomethyl)amine 
• 6096-81-7 dimethyl iminodiacetate 
• 100-39-0 benzyl bromide 
• 96-32-2 bromoacetic acid methyl ester 
• 100-46-9 benzylamine 
• 100-44-7 benzyl chloride 
• 142-73-4 iminodiacetic acid 
• 3987-53-9 N-benzyliminodiacetic acid 

Downstream Products

• 148528-45-4 dimethyl-1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate 
• 148528-46-5 dimethyl 1-benzyl-3,4-dimethoxypyrrole-2,5-dicarboxylate 
• 169616-08-4 dimethyl 1-benzyl-3,4-ethylenedioxypyrrole-2,5-dicarboxylate 
• 169616-07-3 dimethyl 1-benzyl-3,4-diethoxypyrrole-2,5-dicarboxylate 
• 169616-09-5 dimethyl 3,4-bis-(2-methoxyethoxy)-1-benzylpyrrole-2,5-dicarboxylate 
• 35975-17-8 4-benzyl-piperazine-2,6-dione 
• 3987-53-9 N-benzyliminodiacetic acid 
• 6096-81-7 dimethyl iminodiacetate 
• 1339873-06-1 Re(CO)3(C₆H₅CH₂N(CH₂CO₂)2)^(1-)*H⁽¹⁺⁾=[Re(CO)3(C₆H₅CH₂N(CH₂CO₂)2)]H 
• 1339873-07-2 ⁽⁹⁹⁾Tc(CO)3(C₆H₅CH₂N(CH₂CO₂)2)^(1-) 
• 178170-09-7 dimethyl 1-benzyl-3,4-didecyloxypyrrole-2,5-dicarboxylate 
• 178170-08-6 dimethyl 1-benzyl-3,4-dioctyloxypyrrole-2,5-dicarboxylate 
• 178170-05-3 dimethyl 1-benzyl-3,4-dibutoxypyrrole-2,5-dicarboxylate 
• 169616-10-8 dimethyl 1-benzyl-3,4-dihexyloxypyrrole-2,5-dicarboxylate 

Relevant academic research and scientific papers

Synthetic method for preparing marine alkaloid Bacuacuacuanin-L intermediate

The invention discloses a synthesis method for preparing a marine alkaloid Baculiferin-L intermediate. According to the method, a novel synthesis route suitable for the Baculiferin-L intermediate is designed, which is started from a raw material, substitu

IONIZABLE CATIONIC LIPID FOR RNA DELIVERY

What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons;R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons;L1 and L2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons;X1 is S or O;R3 is a linear or branched alkylene consisting of 1 to 6 carbons; andR4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

Substance related with tophatib and preparation method and application thereof

The invention discloses a substance related with tophatib and a preparation method and application thereof. The substance is named as N,N'-diacetyl{(3R,4R)-4-methyl-3-[methyl(7H-pyrrole[2,3-D]pyrimidine-4-yl)amine]piperidine-1-yl}imine. The impurity is characterized in that the generation level is lower in the condensation reaction process; however, the impurity has the uniform main functional groups with the tophatib, the cleaning effect is limited in the subsequent salting and refining process, and the influence to the qualities of crude drug and finished product of tophatib is larger; by detecting the existence of the impurity, the qualities of the raw material and preparation of the tophatib can be effectively determined.

Effective synthesis of 99mTc tricarbonyl complexes by microwave heating

Technetium-99m (99mTc) is one of the most frequently used nuclides for single-photon emission computed tomography (SPECT) imaging because of its radiochemical characteristics, such as gamma emission of suitable energy (141 keV) and adequate half-life (6.01 h). Although triaquatricarbonyl 99mTc cation ([99mTc(CO)3(H2O) 3]+) has several advantages as a 99mTc-labeling agent, e.g., compact chelate size, chelate stability, and simplicity of preparation, its synthetic protocols should be improved. Because microwave heating is a convenient method for synthetic reactions, we studied the effect of microwave irradiation on the synthesis of 99mTc tricarbonyl complexes. We found several factors beneficial for the preparation of nuclear medicines. In particular, microwave heating promoted one-pot syntheses of 99mTc tricarbonyl chelates in a short time. In addition, the 99mTc tricarbonyl complex could be obtained using low concentrations of ligands.

Water-soluble xanthobilirubinic acids?

Xanthobilirubinic acid, a model dipyrrinone for one-half of the bilirubin molecule in photochemical and metabolism studies, is more polar than bilirubin and insoluble in water and in chloroform. Replacing the β-alkyl substituents on the lactam ring of xanthobilirubinic acid with methyl-capped ethylene glycol, diethylene glycol, and triethylene glycol (PEG) groups steadily increased the water solubility of the pigment so that the last is completely soluble in both water and chloroform. Synthesized by base-catalyzed condensation of the corresponding methyl-capped 3,4-diPEG-pyrrolin-2-one with 3,5-dimethyl-4(2-ethoxycarbonylethyl)-2-formyl-1H-pyrrole, these new PEGylated analogs of xanthobilirubinic acid are yellow-colored dipyrrinones that form intermolecular hydrogen-bonded dimers in chloroform solution but are monomeric in methanol and water, as revealed by 1H NMR spectroscopy and vapor pressure osmometry. Methyl xanthobilirubinate has served as a synthetic precursor to bilirubinoids; its amphiphilic PEGylated analogs suggest a route to water-soluble bilirubinoids and biliverdinoids. Graphical abstract: [Figure not available: see fulltext.]

A general method for the synthesis of N-unsubstituted 3,4-diarylpyrrole-2, 5-dicarboxylates

A general method for the synthesis of N-unsubstituted 3,4-diarylpyrrole-2, 5-dicarboxylates (3) has been developed. The key reactions involved are the Hinsberg-type synthesis of dimethyl N-benzyl-3,4-dihydroxypyrrole-2,5- dicarboxylate (6) followed by palladium-catalyzed Suzuki-Miyaura coupling of its bis-triflate derivative (7). The N-benzyl protecting group of the resulting 3,4-diaryl pyrrole-2,5-dicarboxyl ates (8) is cleanly removed under hydrogenolytic or solvolytic conditions.

A new route to porphyrins substituted with long alkoxy groups, attempts to prepare the discotic liquid crystals

Pyrroles substituted with long alkoxy groups are prepared by the reaction of iminodiacetic acid dimethyl ester and dimethyl oxalate and the subsequent alkylation. These pyrroles are good precursor molecules for the corresponding porphyrins, which are expected to form an ordered columnar mesophase and are able to co-ordinate to various metals.

3,4-Dialkoxypyrroles and 2,3,7,8,12,13,17,18-octaalkoxyporphyrins

A five-step general synthesis of 3,4-dialkoxypyrroles 7c-f is described starting with the condensation of dimethyl N-benzyliminodiacetate (1 b) and diethyl oxalate to give dimethyl 1-benzyl-3,4-dihydroxypyrrole-2,5-dicarboxylate (2b), which is bis-O-alkylated to the corresponding 3,4-diethers 3c-g. Pyrrole N-benzyl cleavage followed by ester hydrolysis and decarboxylation leads to 7c-f in 10-50% overall yield. Pyrroles 7c-f react with formaldehyde or benzaldehydes to give meso-H- (8a-d) or meso-tetraaryloctaalkoxyporphyrins 9a-g in moderate yields.