1673-99-0

Usage

Uses

Used in Pharmaceutical Industry:
(2α,5β,6α,18β)-Ibogamine is used as a potential therapeutic agent for addiction and depression treatment due to its ability to modulate neurotransmitter systems in the brain. It has shown promise in treating substance abuse disorders and mental health conditions.
Used in Neuroscientific Research:
(2α,5β,6α,18β)-Ibogamine is used as a research tool to study the interactions between neurotransmitter systems and their role in addiction, depression, and other mental health conditions. Its psychoactive properties make it a valuable compound for understanding the mechanisms of action in the brain.
Used in Regulatory and Safety Assessments:
Due to its psychoactive effects and potential for toxicity, (2α,5β,6α,18β)-Ibogamine is used in regulatory and safety assessments to determine its appropriate use, dosage, and potential risks. This ensures that it can be developed and utilized safely and effectively in medical and therapeutic applications.

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Relevant academic research and scientific papers

Alkaloid studies. 8. Isolation and characterization of alkaloids of Tabernaemontana heyneana Wall and antifertility properties of coronaridine.

In this study, the roots of Tabernaemontana heyneana Wall were examined and the isolation and identification of additional indole alkaloids and some pharmacological properties of coronaridine are described. Extraction of the roots yielded the alkaloids coronaridine, voacangine, ibogamine, 19-oxocoronaridine, and the pseudoindoxyl of voacangine. An acqueous ethanolic extract of the roots was found to prevent fertilization of adult female rats when administered orally. After the residue of this extract was treated chromatographic fractionation on silica gel yielded the alkaloid coronaridine. When administered to adult female rats, orally, coronaridine hydrochloride at levels of 5 mg/kg/day or above prevented pregnancy. Voacangine, assayed by the same procedure, did not prevent pregnancies. Data indicated that coronaridine was weakly estrogenic.

Reductive Heck coupling: An efficient approach toward the iboga alkaloids. Synthesis of ibogamine, epiibogamine and iboga analogs

A mild and efficient synthetic route to the iboga scaffold by employing reductive-Heck type annulation is described. The utility of this process is demonstrated by the direct access to the ibogamine, epiibogamine and iboga-analogs. The cyclization precursors were readily obtained from 2-iodoaniline by heteroannulation reaction with suitable alkynes followed by iodination.

A novel approach to iboga alkaloids: Total synthesis of (±)-ibogamine and (±)-epi-ibogamine

A novel approach to the total synthesis of (±)-ibogamine and (±)-epi-ibogamine, featuring electrophilic substitution at C(2) of N'-CBZ-tryptamine by an allylic acetate, is described.

1,6-dihydro-3(2H)-pyridinones. X. 2-azabicyclooctane Ring Formation via Intramolecular Michael reaction: Total synthesis of (+/-)-Ibogamine and (+/-)-Epiibogamine

A new elaboration method for the 2-azabicyclooctane ring via an intramolecular Michael reaction has been developed and applied to the total synthesis of (+/-)-ibogamine (1) and (+/-)-epiibogamine (2).The unsaturated estert (9) derived from ethyl 1,