167304-98-5

Upstream product

• 121895-18-9 (S)-2-amino-6-hydroxyhexanoic acid methyl ester hydrochloride 
• 6033-32-5 (S)-2-amino-6-hydroxyhexanoic acid 
• 167305-85-3 (S)-2-((S)-4-Acetylsulfanyl-2-benzyloxycarbonylamino-butyrylamino)-6-hydroxy-hexanoic acid methyl ester 
• 167305-86-4 (S)-2-((S)-4-Acetylsulfanyl-2-benzyloxycarbonylamino-butyrylamino)-6-oxo-hexanoic acid methyl ester 
• 167305-87-5 (S)-2-((S)-2-Benzyloxycarbonylamino-4-mercapto-butyrylamino)-6-oxo-hexanoic acid methyl ester 
• 167305-83-1 2-(acetylamino)-2-[4-(acetyloxy)butyl]propanedioic acid, diethyl ester 
• 167305-84-2 2-(Acetylamino)-6-hydroxyhexanoic acid 
• 167305-43-3 (3S,7S,11S)-1-aza-3-benzyloxycarbonylamino-11-methoxycarbonyl-2-oxo-6-thiabicyclo[5.4.0]undecane 

Downstream Products

• 229976-38-9 (4S,6S,9aS)-6-((S)-2-Mercapto-3-phenyl-propionylamino)-5-oxo-octahydro-9-thia-4a-aza-benzocycloheptene-4-carboxylic acid methyl ester 
• 1400677-94-2 (2R,5R)-2,5-dibenzyl-N₁,N₆-bis((4S,7S,10aS)-7-(hydroxymethyl)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)hexanediamide 
• 1400674-89-6 (2R,5R)-2,5-dibenzyl-N₁,N₆-bis((4S,7S,10aS)-7-(methoxymethyl)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-yl)hexanediamide 
• 1400674-92-1 (4S,7S,10aS)-methyl 4-((2R,5R)-2,5-dibenzyl-6-((S)-1-(3-methoxy-3-oxopropyl)-2-oxoazepan-3-ylamino)-6-oxohexanamido)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepine-7-carboxylate 
• 1400676-53-0 (2R,5R)-2,5-dibenzyl-6-((4S,7S,10aS)-7-(methoxycarbonyl)-5-oxooctahydro-2H-pyrido[2,1-b][1,3]thiazepin-4-ylamino)-6-oxohexanoic acid 

Relevant academic research and scientific papers

Dual metalloprotease inhibitors: Mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase

A series of 7,6- and 7,5-fused bicyclic thiazepinones and oxazepinones were generated and incorporated as conformationally restricted dipeptide surrogates in mercaptoacyl dipeptides. These compounds are potent inhibitors of angiotensin-converting enzyme (

COMPOUNDS CONTAINING A FUSED BICYCLE RING AND PROCESSES THEREFOR

Compounds of the formula STR1 wherein X is O or S--(O) t ; n is one or two; m is zero or one; Y is CH 2, O, or S--(O) t provided that Y is O or S--(O) t only when m is one; and A is STR2 are dual inhibitors of NEP and ACE. Compounds wherein A is STR3 are selective ACE inhibitors. Also disclosed are methods of preparation and intermediates.