167390-83-2Relevant academic research and scientific papers
Synthesis of Benzimidazoles through Palladium-Catalyzed Amination of 2-Iodobenzimines with Diaziridinone
Ma, Ding,Ji, Xiaoming,Wu, Zhuo,Cheng, Cang,Zhou, Bo,Zhang, Yanghui
, p. 739 - 746 (2019)
An efficient approach for the synthesis of benzimidazoles has been developed through the Pd-catalyzed amination of 2-iodobenzimines with diaziridinone. A wide range of 2-(hetero)aryl benzimidazloes are synthesized in good to excellent yields. The reactions likely involve C,C-palladacycles derived from 2-iodobenzimines as the key intermediate, and the palladacycles reacted with diaziridinone to form benzimidazoles. (Figure presented.).
Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease
Benek, Ondrej,Soukup, Ondrej,Pasdiorova, Marketa,Hroch, Lukas,Sepsova, Vendula,Jost, Petr,Hrabinova, Martina,Jun, Daniel,Kuca, Kamil,Zala, Dominykas,Ramsay, Rona R.,Marco-Contelles, José,Musilek, Kamil
supporting information, p. 1264 - 1269 (2016/08/06)
Novel indolotacrine analogues were designed, synthesized, and evaluated as potential drugs for the treatment of Alzheimer's disease. By using a multitarget-directed ligand approach, compounds were designed to act simultaneously as cholinesterase (ChE) and
Synthesis of 1,2-dihydropyridines using vinyloxiranes as masked dienolates in imino-aldol reactions
Brunner, Bernhard,Stogaitis, Nicole,Lautens, Mark
, p. 3473 - 3476 (2007/10/03)
The application of vinyloxiranes, substituted with an electron-withdrawing group, as masked dienolates in vinylogous imino-aldol reactions was achieved. Under the reaction conditions highly substituted 1,2-dihydropyridines were obtained in moderate to good yields. Mechanistic studies indicate that the reaction proceeds via the formation of an (E)-amino-α,β-unsaturated aldehyde, followed by isomerization to the (Z)-isomer, cyclization, and elimination of a water molecule, leading to the formation of the 1,2-dihydropyridine.
Palladium-catalyzed intramolecular coupling between aryl iodides and allyl moieties via thermal and microwave-assisted conditions
Lautens, Mark,Tayama, Eiji,Herse, Christelle
, p. 72 - 73 (2007/10/03)
Palladium-catalyzed intramolecular cross-coupling reactions between aryl iodides and allyl moieties were successfully demonstrated in the presence of palladium catalyst, tri-o-tolylphosphine, a tertiary amine, and water. Several kinds of trans-2,4-disubst
