167479-16-5

Usage

Uses

Used in Pharmaceutical and Chemical Research:
1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID is used as a building block for the synthesis of various bioactive compounds, such as pharmaceuticals and agrochemicals. Its unique structure allows for the development of new molecules with potential therapeutic and agricultural applications.
Used in Organic Synthesis:
1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID is utilized as a reagent in organic synthesis, contributing to the creation of complex organic molecules and facilitating advancements in chemical research.
Used in Drug Discovery:
As a key compound in medicinal chemistry, 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID is employed in drug discovery processes to identify and develop new pharmaceutical agents with improved efficacy and safety profiles.

Upstream product

• 167479-21-2 methyl 1-methyl-1H-indole-7-carboxylate 
• 208772-25-2 benzyl 1-methylindole-7-carboxylate 
• 69047-36-5 1-methyl-1H-indole-7-carboxaldehyde 
• 1074-88-0 1H-indole-7-carbaldehyde 
• 53951-34-1 o-nitrobenzaldehyde dibutyl acetal 
• 552-89-6 2-nitro-benzaldehyde 
• 28899-75-4 7-Chloro-1H-indole-2-carboxylic acid 
• 43142-64-9 7-Chloro-1H-indole-2-carboxylic acid ethyl ester 
• 167479-19-8 ethyl 7-carbomethoxy-1-methyl-1H-indole-2-carboxylate 
• 167479-18-7 ethyl 7-carbomethoxy-1H-indole-2-carboxylate 
• 93247-78-0 methyl 1H-indole-7-carboxylate 
• 205873-58-1 ethyl 1H-indole-7-carboxylate 
• 126691-26-7 ethyl 1-methylindole-7-carboxylate 
• 167479-20-1 1-methyl-1H-indole-2,7-dicarboxylic acid 

Relevant academic research and scientific papers

Ruthenium(II)-Catalyzed Highly Chemo- And Regioselective Oxidative C6 Alkenylation of Indole-7-carboxamides

We disclosed the first efficient method for highly chemo- and regioselective C6 alkenylation of indole-7-carboxamides using inexpensive Ru(II) catalyst through chelation assisted C-H bond activation. Electronically diverse indole-7-carboxamides and alkenes react efficiently to produce a wide range of C6 alkenyl indole derivatives. Further the C6 alkenyl indole-7-carboxamides modified to their derivatives through simple chemical transformations. The observed regioselectivity and kinetics has been evidenced by deuterium incorporation and intermolecular competitive studies. In addition, for mechanistic insights, the intermediates were analyzed by HRMS.

Synthesis of highly substituted indole alkaloid species via [4+1] cyclization of nucleophilic carbenes and indole isocyanates

Thermally induced [4+1] cyclization between indole isocyanates and dimethoxycarbene or bis(propylthio)carbene has been achieved with good chemical efficiency. The methodology provides rapid access to fused pyrroloindole substructures commonly found in a variety of indole alkaloid natural products.

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.

Pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4fare defined herein) which are useful as modulators of chemokine receptor a

3-alkyl substituted pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4fare defined herein) which are useful as modulators of chemokine receptor a

3-thienyl and 3-furanyl pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4fare defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.

Benzamide derivatives having a vasopressin antagonistic activity

This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I): wherein R1is aryl optionally substituted with lower alkoxy, etc., R2is lower alkyl, etc., R3is hydrogen, etc., A is NH, etc., E is etc., X is —CH═CH—, —CH═N—, or S, and Y is a condensed heterocyclic group, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.

Synthesis and biological activity of N-(aminoiminomethyl)-1H-indole carboxamide derivatives as Na+/H+ exchanger inhibitors

A series of N-(aminoiminomethyl)-1H-indole carboxamide derivatives were synthesized and their inhibitory potencies against the Na+/H+ exchanger were measured. Variation of the carbonylguanidine group at the 2- to 7- position of the indole ring system showed that a substitution at the 2- position improved the Na+/H+ exchanger inhibitory activity the most in vitro. This led to the synthesis and evaluation of an extensive series of N- (aminoiminomethyl)-1H-indole-2-carboxamide derivatives. Derivatives having an alkyl or substituted alkyl group at the 1-position of the indole ring system showed higher levels of in vitro activities. N-(aminoiminomethyl)-1-(2- phenylethyl)-1H-indole-2-carboxamide (49) had the strongest activity.