167479-16-5

Basic information

• Product Name: 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID
• Synonyms: 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID;1-Methyl-7-indolecarboxylic Acid;1-methylindolyl-7-carboxylic acid
• CAS NO: 167479-16-5
• Molecular Formula: C₁₀H₉NO₂
• Molecular Weight: 175.18
• Mol File: 167479-16-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 389.0±15.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.59±0.10(Predicted)
• CAS DataBase Reference: 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID(167479-16-5)
• EPA Substance Registry System: 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID(167479-16-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 167479-16-5(Hazardous Substances Data)

Usage

General Description

1-Methyl-1H-indole-7-carboxylic acid is a chemical compound with the molecular formula C10H9NO2. It is a derivative of indole and belongs to the class of carboxylic acids. 1-METHYL-1H-INDOLE-7-CARBOXYLIC ACID is used in pharmaceutical and chemical research as a building block for the synthesis of various bioactive compounds, such as pharmaceuticals and agrochemicals. Its structure contains a carboxylic acid group and a methyl group attached to the indole ring, which gives it unique properties and potential biological activities. 1-Methyl-1H-indole-7-carboxylic acid is a valuable reagent in organic synthesis and drug discovery, making it an important compound in the field of medicinal chemistry.

Upstream product

• 167479-21-2 methyl 1-methyl-1H-indole-7-carboxylate 
• 43142-64-9 7-Chloro-1H-indole-2-carboxylic acid ethyl ester 
• 28899-75-4 7-Chloro-1H-indole-2-carboxylic acid 
• 69047-36-5 1-methyl-1H-indole-7-carboxaldehyde 
• 1074-88-0 1H-indole-7-carbaldehyde 
• 53951-34-1 o-nitrobenzaldehyde dibutyl acetal 
• 552-89-6 2-nitro-benzaldehyde 
• 208772-25-2 benzyl 1-methylindole-7-carboxylate 
• 167479-19-8 ethyl 7-carbomethoxy-1-methyl-1H-indole-2-carboxylate 
• 167479-18-7 ethyl 7-carbomethoxy-1H-indole-2-carboxylate 
• 93247-78-0 methyl 1H-indole-7-carboxylate 
• 205873-58-1 ethyl 1H-indole-7-carboxylate 
• 126691-26-7 ethyl 1-methylindole-7-carboxylate 
• 167479-20-1 1-methyl-1H-indole-2,7-dicarboxylic acid 

Relevant articles and documents

Ruthenium(II)-Catalyzed Highly Chemo- And Regioselective Oxidative C6 Alkenylation of Indole-7-carboxamides

We disclosed the first efficient method for highly chemo- and regioselective C6 alkenylation of indole-7-carboxamides using inexpensive Ru(II) catalyst through chelation assisted C-H bond activation. Electronically diverse indole-7-carboxamides and alkenes react efficiently to produce a wide range of C6 alkenyl indole derivatives. Further the C6 alkenyl indole-7-carboxamides modified to their derivatives through simple chemical transformations. The observed regioselectivity and kinetics has been evidenced by deuterium incorporation and intermolecular competitive studies. In addition, for mechanistic insights, the intermediates were analyzed by HRMS.

COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV

The invention aims to provide a dipeptidyl peptidase IV inhibitor which is satisfactory in respect of activity, stability and safety and has an excellent action as a pharmaceutical agent. The invention is directed to a compound represented by the following general formula or a pharmaceutically acceptable salt thereof: wherein R1 and R2 each represents hydrogen, an optionally substituted C1-6 alkyl group, or -COOR5 whereupon R5 represents hydrogen or an optionally substituted C1-6 alkyl group, or R1 and R2, together with a carbon atom to which they are bound, represent a 3- to 6-membered cycloalkyl group, R3 represents hydrogen or an optionally substituted C6-10 aryl group, R4 represents a hydrogen or a cyano group, D represents -CONR6-, -CO- or -NR6CO-, R6 represents hydrogen or an optionally substituted C1-6 alkyl group, E represents -(CH2)m- whereupon m is an integer of 1 to 3, -CH2OCH2-, or -SCH2-, n is an integer of 0 to 3, and A represents an optionally substituted bicyclic heterocyclic group or bicyclic hydrocarbon group.

3-alkyl substituted pyrrolidine modulators of chemokine receptor activity

The present invention is directed to pyrrolidine compounds of the formula I: (wherein R1, R2, R3, R4c, R4d, and R4fare defined herein) which are useful as modulators of chemokine receptor a