16748-73-5Relevant academic research and scientific papers
Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals
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, (2008/06/13)
Polyaspartamide derivatives as adsorbents for bile acids, polyaspartamide derivatives loaded with bile acids and process for their preparation and their use as pharmaceuticals α- or β-linked polyaspartamide derivatives of the formula I STR1 in which RI RII, RIII, RIV, r, s, t, u and v have the stated meanings, are described. They adsorb bile acids and can be used as pharmaceuticals.
SYNTHESIS OF PYROGLUTAMYLASPARAGINE AMIDE DIPEPTIDE FRAGMENT OF VASOPRESSIN, AND THE STEREOSELECTIVITY OF ITS MNEMIC EFFECT
Gudasheva, T. A.,Rozantsev, G. G.,Ostrovskaya, R. U.,Trofimov, S. S.,Voronina, T. A.,et al.
, p. 14 - 17 (2007/10/03)
Four diastereomers of pGlu-Asn-NH2 were synthesized.They were considered on one hand as a peptide analogue of piracetam, and on the other as an N-terminal fragment of the major metabolite of vasopressin 4, Cyt6>AVP(4-9).The influence of these diastereomers on the memory of rats was studied in the passive avoidance conditioned reflex test.It was shown that L-pGlu-L-Asn-NH2 and D-pGlu-D-Asn-NH2 in the same doses facilitate the training of rats; D-pGlu-D-Asn-NH2 is inactive, and L-pGlu-D-Asn-NH2 has amnestic activity.These facts suggest a receptor mechanism for the action of the dipeptide pGlu-Asn-NH2 and are the basis for a hypothesis for the topology of the nootropic receptor binding site.
Peptide Synthesis in Alcohol Solvents by the Mixed Anhydride Method Using Dimethylphosphinothioyl Chloride
Ueki, Masaaki,Saito, Takashi,Sasaya, Jun,Ikeda, Shigeru,Oyamada, Hidekazu
, p. 3653 - 3658 (2007/10/02)
The formation and coupling of the dimethylphosphinothioic mixed anhydrides of protected amino acids can be performed in alcohol solvents.Sparingly soluble protected C-terminal segments of vasoactive intestinal peptide (VIP) up to the heptapeptide stage we
