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2-Ethyl-5-chloro-2-phenyl-pentanenitril is a chemical compound with the molecular formula C14H16ClN. It is an organic nitrile derivative, characterized by the presence of a nitrile group (-CN) and a chloro substituent. 2-Ethyl-5-chlot-2-phenyl-pentansaeurenitril features a pentane backbone with an ethyl group at the 2nd carbon, a phenyl group at the 2nd carbon as well, and a chloro group at the 5th carbon. It is a colorless to pale yellow liquid with a specific boiling point and melting point. Due to its unique structure, it has potential applications in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. However, it is essential to handle 2-Ethyl-5-chlot-2-phenyl-pentansaeurenitril with care, as it may have toxic or hazardous properties.

1676-72-8

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1676-72-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1676-72-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,6,7 and 6 respectively; the second part has 2 digits, 7 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1676-72:
(6*1)+(5*6)+(4*7)+(3*6)+(2*7)+(1*2)=98
98 % 10 = 8
So 1676-72-8 is a valid CAS Registry Number.

1676-72-8Relevant academic research and scientific papers

Discovery of novel non-peptide CCR1 receptor antagonists

Ng, Howard P.,Karen, May,Bauman, John G.,Ghannam, Ameen,Islam, Imadul,Liang, Meina,Horuk, Richard,Hesselgesser, Joseph,Snider, R. Michael,Perez, H. Daniel,Morrissey, Michael M.

, p. 4680 - 4694 (2007/10/03)

Ligands for the CCR1 receptor (MIP-1α and RANTES) have been implicated in a number of chronic inflammatory diseases, most notably multiple sclerosis and rheumatoid arthritis. Because these ligands share a common receptor, CCR1, we sought to discover antagonists for this receptor as an approach to treating these disorders. A novel series of 4-hydroxypiperidines has been discovered by high throughput screening (HTS) which potently inhibits the binding of MIP-1α and RANTES to the recombinant human CCR1 chemokine receptor. The structure-activity relationships of various segments of this template are described as the initial HTS lead 1 was optimized synthetically to the highly potent receptor antagonist 6s. This compound has been shown to have at least 200-fold selectivity for inhibition of CCR1 over other human 7- TM receptors, including other chemokine receptors. In addition, data obtained from in vitro functional assays demonstrate the functional antagonism of compound 6s and structurally related analogues against the CCR1 receptor in a concentration dependent manner. The discovery and optimization of potent and selective CCR1 receptor antagonists represented by compound 6s potentially represent a novel approach to the treatment of chronic inflammatory diseases.

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