167629-40-5

Upstream product

• 824-94-2 p-methoxybenzyl chloride 
• 617-52-7 Dimethyl itakonate 
• 55881-94-2 3-methylene-1,4-dihydroxybutane 
• 1352739-49-1 4-[(4-methoxybenzyl)oxy]-2-methylenebutanal 
• 250209-01-9 4-hydroxy-2-methylenebutanal 
• 289486-00-6 1-(4,4'-dimethoxytrityloxy)-4-(p-methoxybenzyloxy)butan-2-ol 
• 289486-02-8 1-(4,4'-dimethoxytrityloxy)-4-(p-methoxybenzyloxy)butan-2-one 
• 289486-03-9 1-(4,4'-dimethoxytrityloxy)-4-(p-methoxybenzyloxy)-2-methylenebutane 
• 167629-45-0 4-[2-(4-methoxy-benzyloxy)ethyl]-2,2-dimethyl-[1,3]dioxolane 
• 167629-46-1 (p-methoxybenzyloxy)-2-hydroxybutanol 

Downstream Products

• 1026475-63-7 1-{2-[2-(4-methoxy-benzyloxy)-ethyl]-allyl}-5-methyl-1H-pyrimidine-2,4-dione 

Relevant academic research and scientific papers

Towards the synthesis of the 4,19-diol derivative of (-)-mycothiazole: Synthesis of a potential key intermediate

The synthesis of a potential key intermediate for the synthesis of the 4,19-diol derivative of (-)-mycothiazole using convergent strategies is described in this paper. Several approaches have been tested, including cross metathesis and a Julia-Kocienski olefination. Finally, the formation of the 1,1-dialkyl-1,2-ethanediol motif through C4-C5 bond construction was realized by nucleophilic addition of a vinyl iodide derivative to a keto ester after halogen/lithium exchange followed by reduction of the resulting hydroxy ester. The synthesis of the allylic 1,1-dialkyl-1,2-ethanediol group, achieved by halogen/metal exchange followed by addition to aα-keto ester, is the key step of this convergent strategy towards a potential intermediate of mycothiazole-4,19-diol.

Synthesis of unsaturated carboacyclic nucleoside analogues via Mitsunobu reactions

2-Substituted allyl alcohols 9 and 14 were prepared starting from butane-1,2,4-triol and glycerol, respectively. Mitsunobu condensations of 9 and 14 with purine and pyrimidine bases, followed by deprotection, afforded a number of acyclonucleosides having