167629-48-3

Upstream product

• 167629-39-2 tert-butyl{4-[(4-methoxybenzyl)oxy]-2-methylenebutoxy}dimethylsilane 
• 824-94-2 p-methoxybenzyl chloride 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 167629-47-2 1-(tert-Butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-butan-2-ol 
• 167629-45-0 4-[2-(4-methoxy-benzyloxy)ethyl]-2,2-dimethyl-[1,3]dioxolane 
• 167629-46-1 (p-methoxybenzyloxy)-2-hydroxybutanol 

Downstream Products

• 208719-54-4 [2-[1-Benzenesulfonyl-1-fluoro-meth-(E)-ylidene]-4-(4-methoxy-benzyloxy)-butoxy]-tert-butyl-dimethyl-silane 
• 208719-57-7 Benzoic acid 2-[1-fluoro-meth-(Z)-ylidene]-4-(4-methoxy-benzyloxy)-butyl ester 

Relevant academic research and scientific papers

Towards the synthesis of the 4,19-diol derivative of (-)-mycothiazole: Synthesis of a potential key intermediate

The synthesis of a potential key intermediate for the synthesis of the 4,19-diol derivative of (-)-mycothiazole using convergent strategies is described in this paper. Several approaches have been tested, including cross metathesis and a Julia-Kocienski olefination. Finally, the formation of the 1,1-dialkyl-1,2-ethanediol motif through C4-C5 bond construction was realized by nucleophilic addition of a vinyl iodide derivative to a keto ester after halogen/lithium exchange followed by reduction of the resulting hydroxy ester. The synthesis of the allylic 1,1-dialkyl-1,2-ethanediol group, achieved by halogen/metal exchange followed by addition to aα-keto ester, is the key step of this convergent strategy towards a potential intermediate of mycothiazole-4,19-diol.

Terminal fluoroolefins. The synthesis of novel carboacyclic nucleosides

A facile preparation of ketone 7 from butanetriol acetonide 5 is reported, and its utility for the synthesis of novel carboacyclic nucleosides 3E, 3Z, 4E and 4Z by the selective manipulation of multiple functionalities is demonstrated.