16764-90-2Relevant academic research and scientific papers
Cr, Zr-incorporated hydrotalcites and their application in the synthesis of isophorone
Liu, Yanxia,Sun, Kunpeng,Ma, Haowen,Xu, Xianlun,Wang, Xiaolai
, p. 880 - 883 (2010)
Cr3+ and Zr4+ cation-incorporated hydrotalcites (HTs) were prepared by coprecipitation method. Corresponding mixed oxide were obtained by the thermal decomposition of HTs at 773 K for 8 h and applied in the synthesis of isophorone (IP) from acetone. From the characteristic results, both Cr3+ and Zr4+ were introduced into the lattice of hydrotalcite producing the more disordered HT structures. Compared with Mg-Al mixed oxide, Cr and Zr modified mixed oxide demonstrated more amount of basic sites and stronger base strength, which were responsible for the improvement of catalytic activity. As a result, both of the modified mixed oxide exhibited IP selectivity of more than 70% under atmospheric pressure.
Copper(II)-Catalyzed Tandem Decarboxylative Michael/Aldol Reactions Leading to the Formation of Functionalized Cyclohexenones
Lee, Jeonghyo,Wang, Sibin,Callahan, Miranda,Nagorny, Pavel
supporting information, p. 2067 - 2070 (2018/04/16)
This work describes the development of a new single-pot copper(II)-catalyzed decarboxylative Michael reaction between β-keto acids and enones, followed by in situ aldolization, which results in highly functionalized chiral and achiral cyclohexenones. The achiral version of this Robinson annulation features a hitherto unprecedented Michael reaction of β-keto acids with sterically hindered β,β′-substituted enones and provides access to all carbon quaternary stereocenter-containing cyclohexenones (11 examples, 43-83% yield). In addition, an asymmetric chiral bis(oxazoline) copper(II)-catalyzed single-pot Robinson annulation has been devised for preparing chiral cyclohexenones, including some products that contain vicinal stereocenters (5 examples, 65-85% yield, 84-94% ee). This latter protocol has been successfully applied to the enantioselective formation of the oxygenated 10-nor-steroid core from readily available starting materials.
