1677-26-5Relevant academic research and scientific papers
A new paradigm for carbon-carbon bond formation: Aerobic, copper-templated cross-coupling
Villalobos, Janette M.,Srogl, Jiri,Liebeskind, Lanny S.
, p. 15734 - 15735 (2008/09/20)
Thiol esters and boronic acids react to produce ketones under aerobic conditions in the presence of catalytic quantities of a CuI or CuII salt. The reaction occurs at reasonable rates between room temperature and 50 °C at neutral pH using thiol esters derived from bulky 2° amides of thiosalicylamides such as those based on N-tert-butyl-2-mercaptobenzamide. In this mechanistically unprecedented reaction system, the carbon-carbon bond formation occurs through templating of the thiol ester and the boronic acid at copper; the system is rendered catalytic in copper under the aerobic conditions. Copyright
