16781-67-2Relevant articles and documents
A new application of rhodanine as a green sulfur transferring agent for a clean functional group interconversion of amide to thioamide using reusable MCM-41 mesoporous silica
Ray, Suman,Bhaumik, Asim,Dutta, Arghya,Butcher, Ray J.,Mukhopadhyay, Chhanda
, p. 2164 - 2170 (2013/05/08)
A novel thionation protocol for amide compounds, with the system rhodanine/secondary amine has been discovered. Clean and efficient synthesis of a variety of thioamides can be achieved through this simple and convenient method using MCM-41 mesoporous silica as an acid catalyst. For this purpose we have synthesized MCM-41 silica and characterized by using an array of sophisticated analytical techniques like BET, HR TEM, EDX, XRD, 29Si MAS NMR and FTIR. This reaction is therefore a very neat example of a functional group interconversion.
2-Dialkylamino-thiazolin-4-ones from α-Thiocyanato-carboxylic Acid Derivatives
Zimmermann, T.,Fischer, G. W.,Olk, B.
, p. 540 - 546 (2007/10/02)
α-Thiocyanato-acetic acid esters 1 a-c or amide 1 d react with dialkylamine salts of weak acids to give 2-dialkylamino-thiazolin-4-ones 2 a-f.The reaction can be performed using aliphatic alcohols, dipolar aprotic solvents or halogenated hydrocarbons as reaction medium or by heating the educts at 90 deg C without any solvent.According to the latter method, the 5-substituted thiazolinones 2 g, h are obtained from α-thiocyanatopropionic acid ethyl ester (1 d) or α-thiocyanato-phenylacetic acid ethyl ester (1 e) and dimethylamine actetate. - I.r., u.v. and n.m.r. data of the thiazolinones 2 are reported.
