1530-89-8

Basic information

• Product Name: 4-MORPHOLINECARBONITRILE
• Synonyms: N-CYANOMORPHOLINE;N-CYANMORPHOLINE;MORPHOLINO-N-CARBONITRILE;4-MORPHOLINECARBONITRILE;morpholine-4-carbonitrile;4-MORPHOLINECARBONITRILE 97%;4-Morpholinecarbonitrile, 97+%;4-Cyanomorpholine
• CAS NO: 1530-89-8
• Molecular Formula: C₅H₈N₂O
• Molecular Weight: 112.13
• EINECS: 216-235-9
• Product Categories: Aromatic Morpholines;Building Blocks;Heterocyclic Building Blocks;Morpholines
• Mol File: 1530-89-8.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 71-73 °C0.6 mm Hg(lit.)
• Flash Point: 220 °F
• Appearance: clear colourless liquid
• Density: 1.109 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0175mmHg at 25°C
• Refractive Index: n20/D 1.473(lit.)
• PKA: -6.85±0.20(Predicted)
• CAS DataBase Reference: 4-MORPHOLINECARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MORPHOLINECARBONITRILE(1530-89-8)
• EPA Substance Registry System: 4-MORPHOLINECARBONITRILE(1530-89-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 1530-89-8(Hazardous Substances Data)

Usage

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

4-Morpholinecarbonitrile was used in the synthesis of substituted heterocyclic compounds.

General Description

He I and He II photoelectron spectra of 4-morpholinecarbonitrile has been investigated.

InChI:InChI=1/C5H8N2O/c6-5-7-1-3-8-4-2-7/h1-4H2

Upstream product

• 110-91-8 morpholine 
• 151-50-8 potassium cyanide 
• 5625-98-9 morpholinoethyl amide 
• 696-57-1 N-allylmorpholine 
• 506-68-3 bromocyane 
• 7677-24-9 trimethylsilyl cyanide 
• 172876-96-9 3-oxo-1λ³-benzo[d][1,2]iodaoxole-1(3H)-carbonitrile 
• 35891-13-5 2,2,2-trichloro-1-morpholinoethanimine 
• 1271-28-9 nickelocene 
• 2158-02-3 morpholine-4-carboxylic acid amide 
• 542-90-5 ethyl isothiocyanate 
• 23328-69-0 4-chloromorpholine 

Downstream Products

• 4394-85-8 4-morpholinecarboxaldehyde 
• 1696-20-4 4-acetylmorpholine 
• 935700-58-6 6-(4-chlorophenyl)-2-(morpholin-4-yl)pyridin-4-ol 
• 935700-59-7 6-(4-methoxyphenyl)-2-(morpholin-4-yl)pyridin-4-ol 
• 117239-20-0 2-(4-Morpholinyl)-6-(phenylthiomethyl)-1,4,3-oxathiazin-4,4-dioxid 
• 117239-21-1 6-(4-Chlorophenylthiomethyl)-2-(4-morpholinyl)-1,4,3-oxathiazin-4,4-dioxid 
• 117239-33-5 5-(Anilino-sulfonylmethyl)-3-(4-morpholinyl)-4H-1,2,4-thiadiazin-1,1-dioxid 
• 117239-28-8 6-(Anilino-sulfonylmethyl)-2-(4-morpholinyl)-1,4,3-oxathiazin-4,4-dioxid 
• 117239-27-7 6-(Benzylamino-sulfonyl-methyl)-2-(4-morpholinyl)-1,4,3-oxathiazin-4,4-dioxid 
• 117239-32-4 5-(Benzylamino-sulfonylmethyl)-3-(4-morpholinyl)-4H-1,2,4-thiadiazin-1,1-dioxid 
• 128118-71-8 Morpholine-4-carboxylic acid phenylacetyl-amide 
• 1373613-17-2 C₁₃H₁₆N₂O₂ 
• 1620330-12-2 2,4-bis(4-methylphenyl)-6-morpholin-4-yl-1,3,5-triazine 
• 1620330-13-3 2,4-dicyclohexyl-6-morpholin-4-yl-1,3,5-triazine 

Relevant articles and documents

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N-Cyanation of Primary and Secondary Amines with Cyanobenzio-doxolone (CBX) Reagent

An efficient electrophilic N-cyanation of amines with a stable and less-toxic cyanobenziodoxole reagent towards the synthesis of cyanamides is disclosed. This synthetically practicable strategy allows the construction of a wide variety of cyanamides under very mild and simple conditions with a broad functional group compatibility, and showcases a huge potential in late-stage modification of complex molecules.

Benzoxazinone derivatives and their use as antibacterial agents

The invention discloses benzoxazinone derivatives, a synthesis method and applications thereof. The derivatives can be used as an antibacterial agent for treating infectious diseases caused by bacteria, especially tuberculosis (TB) caused by mycobacterium. Specifically, the invention relates to compounds represented by the formula (I), pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the provided compounds; wherein the R1 to R4 are defined in the description. The invention aim to prepare novel compounds capable of inhibiting the mycobacterium activity, the compounds can be used as a potential novel drug for treating infectious diseases caused by bacteria, moreover, the compounds can be used to treat or prevent tuberculosis (TB) caused by mycobacterium, at the same time the problems related with drug resistance can be solved, and the drug metabolism property can be improved on the basis that the mycobacterium tuberculosis resistant activity is not influenced.