5349-28-0

Basic information

• Product Name: ETHYL 2-THIOCYANATOACETATE
• Synonyms: ETHYL 2-THIOCYANATOACETATE;ethylthiocyanatoacetate;ethylthiocyanoacetate;ree(acetate);thiocyanatoaceticacidethylester;thiocyanato-aceticaciethylester;Sassen;ETHYLRHODANACETATE
• CAS NO: 5349-28-0
• Molecular Formula: C₅H₇NO₂S
• Molecular Weight: 145.18
• Mol File: 5349-28-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 122 °C
• Flash Point: 89.4°C
• Appearance: /
• Density: 1.252 (estimate)
• Vapor Pressure: 2.15E-06mmHg at 25°C
• Refractive Index: 1.5216 (estimate)
• CAS DataBase Reference: ETHYL 2-THIOCYANATOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-THIOCYANATOACETATE(5349-28-0)
• EPA Substance Registry System: ETHYL 2-THIOCYANATOACETATE(5349-28-0)

Safety Data

• Hazardous Substances Data: 5349-28-0(Hazardous Substances Data)

Usage

General Description

ETHYL 2-THIOCYANATOACETATE is a chemical compound with the molecular formula C5H7NO2S. It is an organosulfur compound that contains a thiocyano group and an ethyl ester functional group. ETHYL 2-THIOCYANATOACETATE is commonly used as a reagent in organic synthesis, particularly in the preparation of various sulfur-containing compounds. It is also known for its ability to inhibit the growth of certain microorganisms and is therefore used in the development of antimicrobial agents. Additionally, ETHYL 2-THIOCYANATOACETATE has been studied for its potential pharmacological properties, particularly its ability to act as an antitumor agent. ETHYL 2-THIOCYANATOACETATE has potential applications in various fields, including pharmaceuticals, agrochemicals, and materials science.

InChI:InChI=1/C13H18O4/c1-7(14)17-13(12(15)16)10-3-8-2-9(5-10)6-11(13)4-8/h8-11H,2-6H2,1H3,(H,15,16)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 1147550-11-5 ammonium thiocyanate 
• 333-20-0 potassium thioacyanate 
• 105-39-5 chloroacetic acid ethyl ester 
• 623-73-4 diazoacetic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 2911-22-0 6-methyl-4-oxo-2-thioxo-3,4-dihydro-2H-1,3-oxazine 
• 64-17-5 ethanol 

Downstream Products

• 120972-05-6 thiazolidine-2,4-dione-2-dimethylhydrazone 
• 623-51-8 ethyl 2-sulfanylacetate 
• 75-15-0 carbon disulfide 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 37061-82-8 3-Chloro-2-[(2-chloro-1-ethoxycarbonyl-2-phenyl-ethylsulfanylcarbonylamino)-phenyl-methylcarbamoylsulfanyl]-3-phenyl-propionic acid ethyl ester 
• 37061-83-9 3-Chloro-2-[[2-chloro-2-(4-chloro-phenyl)-1-ethoxycarbonyl-ethylsulfanylcarbonylamino]-(4-chloro-phenyl)-methylcarbamoylsulfanyl]-3-(4-chloro-phenyl)-propionic acid ethyl ester 
• 37061-84-0 3-(4-Bromo-phenyl)-2-{(4-bromo-phenyl)-[2-(4-bromo-phenyl)-2-chloro-1-ethoxycarbonyl-ethylsulfanylcarbonylamino]-methylcarbamoylsulfanyl}-3-chloro-propionic acid ethyl ester 
• 2295-31-0 thiazoline-2,4-dione 
• 3189-57-9 4-methylpyridinium dicyanomethylide 
• 26960-15-6 3,5-dimethylpyridinium dicyanomethylide 
• 50737-38-7 1-(1-cyano-2-oxo-2-phenyl-ethyl)-pyridinium betaine 
• 17281-70-8 pyridinium cyanoi(ethoxycarbonyl)methylide 
• 27032-01-5 pyridinium 1-dicyanomethylide 

Relevant articles and documents

Thiocyanation and 2-Amino-1,3-thiazole Formation in Water Using Recoverable and Reusable Glycosylated Resorcin[4]arene Cavitands

A family of three spatially directional resorcin[4]arene cavitand glycoconjugates (RCGs) have been applied as efficient recoverable and reusable inverse phase transfer catalysts for eco- A nd environmentally friendly thiocyanation and 2-amino-1,3-thiazole formation reactions in water. The results show that RCGs (1 mol %) were capable of hosting and catalyzing various water-insoluble bromo/thiocyanato substrates in water without the use of any co-organic solvents. The recoverability and reusability of RCG catalytic systems, that is, RCG1 and RCG3, were also examined upon a simple extraction of the desired products using DCM or ethyl acetate, followed by subjecting the recovered aqueous solution containing the RCG catalysts to the next reaction cycles.

Free-Radical Carbocyanation of Olefins

The free-radical three-component carbocyanation of electron-rich olefins was investigated with p-tosyl cyanide as cyanide source. The scope and limitations of the process were established by varying the nature of the alkene and radical precursor. Carbocyanation of chiral allylsilanes was shown to occur with high diastereocontrol, leading to syn β-silyl nitriles. The origin of the stereocontrol was rationalized by a Felkin–Anh-type transition-state model. Finally, a tin-free carbocyanation process was also devised, based on the use of a new alkylsulfonyl cyanide incorporating both carbon fragments to be added across the olefinic π system.

Thiazolinone 2-substituted quinolines

Thiazolinone substituted quinoline derivatives where the quinoline ring is substituted at the 2 position which derivatives demonstrates CDK1 antiproliferative activity and are useful as anti-cancer agents.