167832-25-9

Upstream product

• 501-53-1 benzyl chloroformate 
• 694-05-3 1,2,3,6-tetrahydropyridine 
• 66207-23-6 1-benzyloxycarbonyl-1,2,3,6-tetrahydropyridine 
• 66207-08-7 3,4-epoxy-piperidine-1-carboxylic acid benzyl ester 
• 937-14-4 3-chloro-benzenecarboperoxoic acid 
• 174681-58-4 5,6-dihydropyridine-1(2H)-carboxylate 
• 1624258-63-4 rac-benzyl 7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylate 

Downstream Products

• 724787-54-6 (3S,4S)-4-tert-butoxycarbonylamino-3-hydroxypiperidine-1-carboxylic acid benzyl ester 
• 724787-53-5 C₁₈H₂₆N₂O₅ 
• 1033748-33-2 (3-methoxypiperidin-4-yl)carbamic acid tert-butyl ester 
• 1007596-96-4 (3R,4R)-tert-butyl 3-azido-4-[(diphenylmethylene)amino]piperidine-1-carboxylate 
• 1007596-93-1 tert-butyl (3R,4R)-4-[(diphenylmethylene)amino]-3-hydroxypiperidine-1-carboxylate 
• 1007596-95-3 (3R,4R)-tert-butyl 4-amino-3-hydroxypiperidine-1-carboxylate 
• 1007596-66-8 benzyl (3S,4R)-4-amino-3-azidopiperidine-1-carboxylate 
• 1007596-67-9 benzyl (3S,4R)-3-azido-4-[(3,4-dichloro-5-methyl-1H-pyrrole-2-carbonyl)amino]piperidine-1-carboxylate 
• 1007596-65-7 benzyl (3S,4R)-3-azido-4-(benzhydrylideneamino)piperidine-1-carboxylate 
• 1007596-64-6 benzyl (3R,4R)-4-(benzhydrylideneamino)-3-hydroxy-piperidine-1-carboxylate 

Relevant academic research and scientific papers

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof: (I) The terms Z, Y, and R1 are as defined in the claims.

BETA-LACTAMASE INHIBITORS

Described herein are compounds and compositions that modulate the activity of beta-lactamases. In some embodiments, the compounds described herein inhibit beta-lactamase. In certain embodiments, the compounds described herein are useful in the treatment of bacterial infections.

1H-PYRROLO[2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

The inventions relates to compounds of (I) and therapeutic uses thereof : (I) The terms Z, Y, and R1 are as defined in the claims.

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases

We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.

Pim kinase inhibitors and methods of their use

The present invention relates to new compounds of Formulas I and II, their tautomers, stereoisomers and polymorphs, and pharmaceutically acceptable salts, esters, metabolites or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the inhibition of Pim kinase activity and/or the prophylaxis or treatment of cancer.

Straightforward and scalable synthesis of orthogonally protected 3,7-diazabicyclo[4.1.0]heptane

Orthogonally N-protected (Boc and Cbz) 3,4-aziridinopiperidine is a versatile building block for the synthesis of 4-substituted 3-aminopiperidines, which are compounds with a high potential for biological activity. A multigram synthesis over five steps, starting with extraordinarily simple materials (pyridine and benzyl chloride), was developed. Georg Thieme Verlag Stuttgart.

PYRROLOPYRIDINES AS KINASE INHIBITORS

Compounds of Formula (I) are useful for inhibition of CHKl and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.

PYRROLOTRIAZINE COMPOUNDS AS KINASE INHIBITORS

The present invention provides compounds of formula (I); and pharmaceutically acceptable salts thereof. The formula (I) compounds inhibit tyrosine kinase activity of growth factor receptors such as HER1, HER2 and HER4 thereby making them useful as antiproliferative agents. The formula (I) compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.

Regio- and stereo-controlled copper organometallic addition to a piperidinyl aziridine: Synthesis of trans 3-amino-4-alkyl-piperidines

3,4-Piperidinyl aziridine N-phosphonate underwent ring opening in Grignard addition catalyzed by a copper reagent to yield trans 3-amino-4-alkyl-piperidines. The nucleophilic addition occurred trans to the aziridine group and regioselectively at C-4 position of the piperidine ring. The high regioselectivity was rationalized by steric argument based on conformational analysis.