167886-56-8Relevant articles and documents
Deacetylative Amination of Acetyl Arenes and Alkanes with C-C Bond Cleavage
Hyodo, Kengo,Hasegawa, Genna,Maki, Hiroya,Uchida, Kingo
, p. 2818 - 2822 (2019/04/25)
The Br?nsted acid-catalyzed synthesis of primary amines from acetyl arenes and alkanes with C-C bond cleavage is described. Although the conversion from an acetyl group to amine has traditionally required multiple steps, the method described herein, which uses an oxime reagent as an amino group source, achieves the transformation directly via domino transoximation/Beckmann rearrangement/Pinner reaction. The method was also applied to the synthesis of γ-aminobutyric acids, such as baclophen and rolipram.
Preparation method and use of lorcaserin hydrochloride
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Paragraph 0019; 0020, (2017/08/28)
The invention provides a preparation method of lorcaserin hydrochloride, wherein the preparation method comprises the synthetic route described in the specification. The preparation method of lorcaserin hydrochloride has the advantages of simpliness, cheap and easily available raw materials, convenient and safe post-processing, and more green and environmental-protection preparation process, and is an economic synthetic method which can be industrialized.
A kind of products and intermediates green card color forest hydrochloride method for the preparation of (by machine translation)
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Paragraph 0047; 0048; 0049, (2016/10/07)
The invention relates to the field of pharmaceutical chemistry, in particular relates to a diet green card color forest hydrochloride method for the preparation of intermediates thereof. The utility model is characterized in that the preparation method comprises: to the chlorobenzene ethylamine as raw materials, after sequentially acidylated protecting amino group, allyl substituted, deprotected, gram alkylate tougheness, split, a green card color forest of the hydrochloric acid salt. green card color forest hydrochloric acid of the present invention and wherein the intermediate preparation method is low in cost, simple in operation, after treatment is convenient, is an economical, can be industrial synthetic method. (by machine translation)