1679-08-9

Usage

Uses

Used in Gas Industry:
2,2-Dimethylpropanethiol is used as a scent additive in natural gas for its strong odor, which aids in the easy detection of gas leaks, enhancing safety measures.
Used in Organic Synthesis:
2,2-Dimethylpropanethiol serves as a precursor to other organic compounds, playing a crucial role in the synthesis of various chemical products.
Used in Flavor and Fragrance Industries:
Despite its unpleasant smell, 2,2-dimethylpropanethiol has been studied for its potential application in the flavor and fragrance industries due to its distinctive olfactory properties, which can be harnessed to create unique scents in a controlled manner.

Upstream product

• 2346-07-8 neopentyl tosylate 
• 463-82-1 2,2-dimethylpropane 
• 75-84-3 2,2-dimethyl-propanol-1 
• 753-89-9 neopentyl chloride 
• 630-17-1 2,2-dimethylpropyl bromide 
• 81193-96-6 2,2-dimethyl-propanethial 
• 13132-23-5 2,2-dimethylpropylmagnesium chloride 
• 101859-65-8 1-Ethoxy-2,2-dimethyl-propane-1-thiol 
• 7704-34-9 sulfur 

Downstream Products

• 80319-00-2 S-(2,2-dimethylpropyl) benzenethiosulfinate 
• 86810-74-4 1-(2,2-dimethylpropylsulfanyl)-4-nitrobenzene 
• 6079-57-8 neopentyl methyl sulfide 
• 928649-57-4 4-(2,2-dimethylpropane-thiomethyl)-benzonitrile 
• 1574556-04-9 C₂₅H₃₁Cl₂NO₂S 
• 76697-49-9 Neopentyl-(2-nitrophenyl)-sulfon 
• 86810-75-5 Neopentyl-(4-nitrophenyl)-sulfon 
• 76697-42-2 Neopentyl-(2-nitrophenyl)-sulfid 
• 84850-25-9 phenacyl neopentyl sulfide 

Relevant academic research and scientific papers

Visible-Light-Induced Passerini Multicomponent Polymerization

Herein, we introduce an additive-free visible-light-induced Passerini multicomponent polymerization (MCP) for the generation of high molar mass chains. In place of classical aldehydes (or ketones), highly reactive, in situ photogenerated thioaldehydes are exploited along with isocyanides and carboxylic acids. Prone to side reactions, the thioaldehyde moieties create a complex reaction environment which can be tamed by optimizing the synthetic conditions utilizing stochastic reaction path analysis, highlighting the potential of semi-batch procedures. Once the complex MCP environment is understood, step-growth polymers can be synthesized under mild reaction conditions which—after a Mumm rearrangement—result in the incorporation of thioester moieties directly into the polymer backbone, leading to soft matter materials that can be degraded by straightforward aminolysis or chain expanded by thiirane insertion.

AMINO TRIAZOLES AS PI3K INHIBITORS

The invention relates to compounds of formula (I) Said compounds are useful as protein kinase inhibitors, especially inhibitors of P13K, for the treatment or prophylaxis of immunological, inflammatory, autoimmune, or allergic disorders. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the production of and use as medicaments.

6-ARYLALKYLAMINO- 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINES AS 5-HT2C RECEPTOR AGONISTS

The present invention provides 6-substituted 2,3,4,5-tetrahydro-lH- benzo[d]azepines of Formula (I) as selective 5-HT2c receptor agonists for the treatment of 5-HT2c associated disorders including obesity, obsessive/compulsive disorder, depression, and anxiety, where, R6 is -NR10R11, where R10 is substituted phenylalkyl or substituted pyridylalkyl and other substituents are as defined in the specification.

Gas-phase SN2 and E2 reactions of alkyl halides

Rate coefficients have been measured for the gas-phase reactions of methyl, ethyl, n-propyl, isopropyl, tert-butyl, and neopentyl chlorides and bromides with the following set of nucleophiles, listed in order of decreasing basicity: HO-, CH3O-, F-, HO- (H2O), CF3CH2O-, H2NS-, C2F5CH2O-, HS-, and Cl-. For methyl chloride the reaction efficiency first falls significantly below unity with HO- (H2O) as the nucleophile and for methyl bromide with HS- as the nucleophile; in both cases the overall reaction exothermicity is about 30 kcal mol-1. Earlier conclusions that these halides react slowly with stronger bases are shown to be in error. In the region where the rates are slow oxygen anions react with the alkyl chlorides and bromides by elimination while sulfur anions of the same basicity react by substitution. This difference is due to a slowing down of elimination with the sulfur bases; sulfur anions show no increased nucleophilicity as compared to oxy anions of the same basicity. Rate coefficients have also been measured for reaction of methyl fluoride with HO- and CH3O- and ethylene oxide with HO-, CH3O-, and F-. All of these rates are slow but measurable; combining the results of these experiments with those of the alkyl chlorides and bromides suggests that the gas-phase barrier to the symmetrical SN2 reaction of F- with methyl fluoride is lower than previous estimates. We have also measured rates for reaction of allyl chloride with F-, H2NS-, and HS-, chloromethyl ether with H2NS- and HS-, chloroacetonitrile with F-, H2NS-, HS-, and 37Cl-, bromoacetonitrile with Cl- and 81Br-, and α-chloroacetone with H2NS-, HS-, and 37Cl-. Our results also imply that the gas-phase SN2 barrier for Br- reacting with methyl bromide is nearly equal to the ion-dipole attraction energy of the reactants, in agreement with previous estimates.

149. Notizen zur Synthese von 2-Aminophenylsulfonen

Syntheses of the alkyl, cycloalkyl and aryl 2-aminophenyl sulfones 10 were achieved by oxidation of the corresponding 2-nitrophenyl sulfides 7 to the 2-nitrophenyl sulfones 9 followed by ethanolic Bechamp-reduction.The sulfides 7 in turn were obtained by either reactions of 2-nitro-thiophenol (8) with the appropriate alkyl and cycloalkyl halides or of 2-chloro-nitrobenzene (5) with the relevant thiols.Condensation of 2-nitrobenzenesulfinic acid (3) with bromoacetic acid in aqueous alkaline solution led - presumably via 2-nitrophenylsulfonylacetic acid (4) - to methyl2-nitrophenyl sulfone (1), reduction of which gave 2-aminophenyl methyl sulfone (2).Treatment of 2-aminothiophenol (11) with t-butyl alcohol in aqueous sulfuric acid gave 2-aminophenyl t-butyl sulfide (12), which was acetylated to o-t-butylthio-acetanilide (13).Oxidation of the latter to o-t-butylsulfonyl-acetanilide (14) followed by hydrolysis led to 2-aminophenyl t-butyl sulfone (15).