1679-41-0

Upstream product

• 37428-46-9 3-chloro-2-buten-1-ol 
• 67-64-1 acetone 
• 68-12-2 N,N-dimethyl-formamide 
• 10025-87-3 trichlorophosphate 

Downstream Products

• 126956-13-6 1-(p-methoxyphenylamino)-3-(p-methoxyphenylimino)-1-butene hydrochloride 
• 58787-21-6 ethyl 2-phenyl-4-methyl-3-pyridinecarboxylate 

Relevant academic research and scientific papers

Efficient selective oxidation of organic substrates using pyridinum sulfonate halochromate under solvent-free conditions and microwave irradiation: Experimental and theoretical study

A convenient and rapid method has been developed for the selective oxidation of several types of alcohols to related carbonyl compounds under solvent-free conditions. In this study, the authors report the microwave-assisted selective oxidation of alcohols and a number of organic compounds with pyridinum sulfonate chlorochromate (PSCC) and pyridinum sulfonate fluorochromate (PSFC). The density functional theory calculations were made at B3LYP/6-31G* levels of theory and thermodynamic data supported the proposed mechanism involving formation of a halochromate ester, which showed that PSFC should be a more capable oxidant than PSCC. The oxidation products are easily obtained in short reaction time with good yields.

An efficient selective oxidation of alcohols with potassium permanganate adsorbed on aluminum silicate under solvent-free conditions and shaking

A new procedure for the selective oxidation of alcohols to the corresponding aldehydes and ketones with potassium permanganate supported on aluminum silicate at room temperature under solvent-free conditions and shaking is reported. Springer-Verlag 2006.

Shaken not stirred; Oxidation of alcohols with sodium dichromate

Efficient and selective oxidation of primary alcohols to the corresponding aldehydes with sodium dichromate at room temperature under solvent-free conditions by shaking is described. This new procedure can also successfully oxidise secondary alcohols.

In vitro metabolism of chloroprene: Species differences, epoxide stereochemistry and a de-chlorination pathway

Chloroprene (1) was metabolized by liver microsomes from Sprague-Dawley rats, Fischer 344 rats, B6C3F1 mice, and humans to the monoepoxides, (1-chloro-ethenyl)oxirane (5a/5b), and 2-chloro-2-ethenyloxirane (4a/4b). The formation of 4a/4b was inferred from the identification of their degradation products. With male Sprague-Dawley and Fischer 344 rat liver microsomes, there was a ca. 3:2 preference for the formation of (R)-(1-chloroethenyl)oxirane (5a) compared to the (S)-enantiomer (5b). A smaller but distinct enantioselectivity in the formation of (S)-(1-chloro-ethenyl)oxirane occurred with liver microsomes from male mouse (R:S, 0.90:1) or male human (R:S, 0.86:1). 2-Chloro-2-ethenyloxirane was very unstable in the presence of the microsomal mixture and was rapidly converted to 1-hydroxybut-3-en-2-one (11) and 1-chlorobut-3-en-2-one (12). An additional rearrangement pathway of 2-chloro-2-ethenyloxirane gave rise to 2-chlorobut-3-en-1-al (14) and 2-chlorobut-2-en-1-al (15). Further reductive metabolism of these metabolites occurred to form 1-hydroxybutan-2-one (17) and 1-chlorobutan-2-one (18). In the absence of an epoxide hydrolase inhibitor, the microsomal incubations converted (1-chloroethenyl)oxirane to 3-chlorobut-3-ene-1,2-diol (21a/21b). When microsomal incubations were supplemented with glutathione, 1-hydroxybut-3-en-2-one was not detected because of its rapid conjugation with this thiol scavenger.

A New Procedure for the Preparation of Aldehydes and Ketones by the Oxidation of Primary and Secondary Alcohols with Potassium Dichromate in a Neutral Benzene-Water System

A new and convenient procedure for the preparation of aldehydes and ketones by the oxidation of the corresponding primary and secondary alcohols with potassium dichromate in a neutral benzene-water system is described.

A new and convenient method for the preparation of aldehydes by oxidation of primary alcohols with chromium trioxide in dimethyl sulfoxide

A new and convenient method is described to oxidize primary alcohols into the corresponding aldehydes utilizing chromium trioxide-dimethyl sulfoxide system.

CHROMIC ACID ADSORBED ON KIESELGUHR: A NEW REAGENT FOR THE OXIDATION OF PRIMARY ALCOHOLS TO ALDEHYDES

A new reagent, chromic acid adsorbed on kieselguhr, suitable for the oxidation of primary alcohols to the corresponding aldehydes is described.