58787-21-6Relevant articles and documents
Facile Synthesis of Onychines
Arita, Mao,Yokoyama, Soichi,Asahara, Haruyasu,Nishiwaki, Nagatoshi
, p. 2007 - 2013 (2019/04/26)
The FeCl 3 -mediated condensation of an α-phenylenamino ester and an enone proceeds efficiently to afford a 2-phenylnicotinate. The subsequent intramolecular Friedel-Crafts reaction yielded an onychine framework. Modifications at the 2-, 3-, and 8-positions of the onychine framework were easily achieved by altering the enamino esters and enones, which facilitated the discovery of potentially bioactive compounds.
Reaction of N-vinylic phosphazenes with α,β-unsaturated aldehydes. Azatriene-mediated synthesis of dihydropyridines and pyridines derived from β-amino acids
Palacios, Francisco,Herran, Esther,Alonso, Concepcion,Rubiales, Gloria,Lecea, Begona,Ayerbe, Mirari,Cossio, Fernando P.
, p. 6020 - 6030 (2007/10/03)
Aza-Wittig reaction of N-vinylic phosphazenes (1,2 addition), derived from diphenylmethylphosphine or derived from trimethylphosphine with α,β-unsaturated aldehydes, leads to the formation of 3-azatrienes through a [2 + 2]-cycloaddition-cycloreversion sequence. The presence of an alkyl substituent in position 3 of N-vinylic phosphazenes increases the steric interactions, and [4 + 2] periselectivity (1,4 addition) is observed. Reaction of azatrienes with α,β-unsaturated aldehydes yields pyridines.
Constituents of tropical medicinal plants, LXIII: Synthesis of 2-methoxyonychine alkaloids - Structure revision of oxylopidine
Achenbach,Schwinn
, p. 755 - 762 (2007/10/02)
Condensation of β-aminocinnamic acid esters with 3-chloro-2-methoxycrotonaldehyde opened an easy access to 2-phenyl-5-methoxy-4-methylnicotinic acid esters which were cyclized by polyphosphoric acid to yield the corresponding 2-methoxyonychines. By this m
