168127-32-0

Basic information

• Product Name: ethyl 2-[4-[2-[(4-methylphenyl)amino]-1,3-thiazol-4-yl]phenoxy]acetate
• Synonyms: ethyl 2-[4-[2-[(4-methylphenyl)amino]-1,3-thiazol-4-yl]phenoxy]acetate
• CAS NO: 168127-32-0
• Molecular Formula: C₂₀H₂₀N₂O₃S
• Molecular Weight: 368.45
• Mol File: 168127-32-0.mol

Chemical Properties

• Boiling Point: 530.6°Cat760mmHg
• Flash Point: 274.7°C
• Appearance: /
• Density: 1.241g/cm³
• Vapor Pressure: 2.43E-11mmHg at 25°C
• Refractive Index: 1.617
• CAS DataBase Reference: ethyl 2-[4-[2-[(4-methylphenyl)amino]-1,3-thiazol-4-yl]phenoxy]acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-[4-[2-[(4-methylphenyl)amino]-1,3-thiazol-4-yl]phenoxy]acetate(168127-32-0)
• EPA Substance Registry System: ethyl 2-[4-[2-[(4-methylphenyl)amino]-1,3-thiazol-4-yl]phenoxy]acetate(168127-32-0)

Safety Data

• Hazardous Substances Data: 168127-32-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C20H20N2O3S/c1-3-24-19(23)12-25-17-10-6-15(7-11-17)18-13-26-20(22-18)21-16-8-4-14(2)5-9-16/h4-11,13H,3,12H2,1-2H3,(H,21,22)

Upstream product

• 29936-82-1 ethyl 4-(bromoacetyl)phenoxyacetate 
• 622-52-6 p-methylphenylthiourea 
• 51828-69-4 ethyl (4-acetylphenoxy)-acetate 
• 754231-46-4 ethyl 4-(2-tosyloxyacetyl)phenoxyacetate 

Downstream Products

• 168127-37-5 4-<2-(p-tolylamino)-4-thiazolyl>phenoxyacetic acid 

Relevant articles and documents

Use of benzene in the synthesis of ethyl 4-(2-substituted amino-4-thiazolyl)phenoxyacetates and acids as antiinflammatory agents

Synthesis of ethyl 4-(2-substituted amino-4-thiazolyl)phenoxyacetates has been accomplished by benzene mediated approach involving condensation of 4-(2-tosyloxyacetyl)phenoxyacetate with appropriate thioureas as well as by the Hantzsch thiazole synthesis using ethyl 4-(2-bromoacetyl)phenoxyacetate.These compounds on acidic hydrolysis furnish the corresponding acids.All the compounds have been tested for antiinflammatory activity by carragenin-induced rat paw edema test and one of them has shown good activity.