754231-46-4

Upstream product

• 27126-76-7 [hydroxy(tosyloxy)iodo]benzene 
• 51828-69-4 ethyl (4-acetylphenoxy)-acetate 

Downstream Products

• 168127-32-0 ethyl 4-<2-(p-tolylamino)-4-thiazolyl>phenoxyacetate 
• 168127-29-5 [4-(2-Amino-thiazol-4-yl)-phenoxy]-acetic acid ethyl ester 
• 168127-31-9 {4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-acetic acid ethyl ester 
• 168127-30-8 [4-(2-Phenylamino-thiazol-4-yl)-phenoxy]-acetic acid ethyl ester 
• 168127-38-6 {4-[2-(4-Chloro-phenylamino)-thiazol-4-yl]-phenoxy}-acetic acid 
• 168127-37-5 4-<2-(p-tolylamino)-4-thiazolyl>phenoxyacetic acid 
• 168127-35-3 [4-(2-Phenylamino-thiazol-4-yl)-phenoxy]-acetic acid 
• 168127-34-2 2-(4-(2-aminothiazol-4-yl)phenoxy)acetic acid 
• 168127-33-1 {4-[2-(4-Chloro-phenylamino)-thiazol-4-yl]-phenoxy}-acetic acid ethyl ester 

Relevant academic research and scientific papers

A facile synthesis of thiazole-2(3H)-thiones through [hydroxy(tosyloxy) iodo]benzene

A one-pot facile synthesis of thiazole-2(3H)-thiones (4) has been achieved by hypervalent iodine oxidation of ketones (1) using [hydroxy (tosyloxy)iodo]benzene, followed by the treatment of the reaction mixture with dithiocarbamate salts (3) The intermediate α-tosyloxy-ketones (2) have also been isolated and converted to the target compounds.

Use of benzene in the synthesis of ethyl 4-(2-substituted amino-4-thiazolyl)phenoxyacetates and acids as antiinflammatory agents

Synthesis of ethyl 4-(2-substituted amino-4-thiazolyl)phenoxyacetates has been accomplished by benzene mediated approach involving condensation of 4-(2-tosyloxyacetyl)phenoxyacetate with appropriate thioureas as well as by the Hantzsch thiazole synthesis using ethyl 4-(2-bromoacetyl)phenoxyacetate.These compounds on acidic hydrolysis furnish the corresponding acids.All the compounds have been tested for antiinflammatory activity by carragenin-induced rat paw edema test and one of them has shown good activity.