29936-82-1

Upstream product

• 51828-69-4 ethyl (4-acetylphenoxy)-acetate 

Downstream Products

• 168127-31-9 {4-[2-(4-Methoxy-phenylamino)-thiazol-4-yl]-phenoxy}-acetic acid ethyl ester 
• 168127-30-8 [4-(2-Phenylamino-thiazol-4-yl)-phenoxy]-acetic acid ethyl ester 
• 168127-33-1 {4-[2-(4-Chloro-phenylamino)-thiazol-4-yl]-phenoxy}-acetic acid ethyl ester 
• 51828-69-4 ethyl (4-acetylphenoxy)-acetate 
• 1113057-21-8 ethyl 2-{4-[2-(5-(2,3-dicarbobenzoxy-1-guanidino)-1-oxo-2,3-dihydro-1H-benzo[c]azol-2-yl)acetyl]phenoxy}-acetate 
• 168127-38-6 {4-[2-(4-Chloro-phenylamino)-thiazol-4-yl]-phenoxy}-acetic acid 
• 168127-37-5 4-<2-(p-tolylamino)-4-thiazolyl>phenoxyacetic acid 
• 168127-35-3 [4-(2-Phenylamino-thiazol-4-yl)-phenoxy]-acetic acid 
• 168127-34-2 2-(4-(2-aminothiazol-4-yl)phenoxy)acetic acid 
• 168127-29-5 [4-(2-Amino-thiazol-4-yl)-phenoxy]-acetic acid ethyl ester 
• 168127-32-0 ethyl 4-<2-(p-tolylamino)-4-thiazolyl>phenoxyacetate 

Relevant academic research and scientific papers

Heterocyclic compouds

A compound of the general formula wherein: n is 0 or 1; M1 is an amino group; Q is an aromatic heterocyclic group containing a basic nitrogen atom; M2 is an imino group; L is a template group; and A is an acidic group, or an ester or amide derivative thereof, or a sulphonamide group; and pharmaceutically acceptable salts and pro-drugs thereof, for use in the treatment of a disease in which platelet aggregation mediated by the binding of adhesion molecules to GPIIb-IIIa is involved. Novel compounds are also disclosed.

Heterocyclic derivatives

Compounds of formula I STR1 and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R13, M2, X1, Z1, Z1a, X2 and A1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Novel intermediates are also disclosed.

Heterocyclic derivatives

Compounds of formula I STR1 and metabolically labile esters and amides thereof, and pharmaceutically acceptable salts thereof, in which R13, M2, X1, Z1, Z1a, X2 and A1 have the meanings given in the specification. The compounds are useful as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa. Intermediates are also disclosed.

Use of benzene in the synthesis of ethyl 4-(2-substituted amino-4-thiazolyl)phenoxyacetates and acids as antiinflammatory agents

Synthesis of ethyl 4-(2-substituted amino-4-thiazolyl)phenoxyacetates has been accomplished by benzene mediated approach involving condensation of 4-(2-tosyloxyacetyl)phenoxyacetate with appropriate thioureas as well as by the Hantzsch thiazole synthesis using ethyl 4-(2-bromoacetyl)phenoxyacetate.These compounds on acidic hydrolysis furnish the corresponding acids.All the compounds have been tested for antiinflammatory activity by carragenin-induced rat paw edema test and one of them has shown good activity.