1682-04-8Relevant academic research and scientific papers
Regiospecific Syn Addition of (Polyfluoroaryl)copper Reagents to Fluorinated Acetylenes: Preparation and Subsequent Functionalization of Internal Vinylcopper Reagents
MacNeil, Kathryn J.,Burton, Donald J.
, p. 4411 - 4417 (1993)
(Pentafluorophenyl)copper (C6F5Cu) can be prepared from a metathesis reaction between C6F5CdX (X = Br or C6F5) and CuY (Y = Cl or Br).The arylcopper reagent undergoes a stereo- and regiospecific syn addition to fluorinated alkynes, which results in the corresponding internal alkenylcopper intermediate.This vinylcopper reagent can be subsequently functionalized with a variety of electrophiles, including aryl, alkyl, allyl, and acyl halides, to afford tetrasubstituted fluoroalkenes.The para-substituted arylcopper analogs also successfully undergo the addition reaction.
Synthesis and Herbicidal Activity of Phenylproparginols
Parlow, John J.,Clark, Robert D.
, p. 2600 - 2609 (2007/10/02)
A three-step/one-pot procedure was developed for preparing herbicidal fluorophenylproparginols from acetophenones by way of an enol phosphate intermediate.Side-by-side testing of 16 of the more active analogs showed that trans-2-methyl-1-2-(4-methoxy-2,3
