168214-68-4Relevant academic research and scientific papers
Kinetic analysis and subambient temperature chromatography of an active ester
Egekeze, John O.,Danielski, Michael C.,Grinberg, Nelu,Smith, George B.,Sidler, Daniel R.,Perpall, Holly J.,Bicker, Gary R.,Tway, Patricia C.
, p. 2292 - 2295 (1995)
The inherent instability of active esters provides a chromatographic challenge. A normal phase HPLC gradient was developed using nonprotic solvents and a diol stationary phase to determine the impurity profile of a mesylate which, under protic conditions,
Improved process for the preparation of montelukast: Development of an efficient synthesis, identification of critical impurities and degradants
Halama, Ales,Jirman, Josef,Bouskova, Olga,Gibala, Petr,Jarrah, A. Kamal
body text, p. 425 - 431 (2011/04/22)
An improved and scalable process for the production of montelukast (Singulair, drug for asthma) based on a new and advantageous method of carrying out the key substitution reaction has been developed. The present procedure is distinguished from the previous solutions in the use of linear or cyclic polyethers, which ensures higher selectivity of the key step. The improved process for the preparation of montelukast is able to minimize a content of impurities and allows the effective production of montelukast and its scale-up.
