1683-86-9

Usage

Uses

Used in Pharmaceutical Industry:
2-amino-5-fluoro-1H-pyrimidin-4-one is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a key component in the development of new drugs, particularly those targeting specific biological pathways or receptors.
Used in Antiviral Applications:
2-amino-5-fluoro-1H-pyrimidin-4-one is used as a building block for the development of antiviral drugs, such as 5-fluorocytosine. It has been synthesized by converting 1,3-dimethyluracil using various reagents like guanidine, thiourea, or urea. 2-amino-5-fluoro-1H-pyrimidin-4-one has shown potential in treating viral infections by interfering with the viral replication process.
Used in Chemical Research:
2-amino-5-fluoro-1H-pyrimidin-4-one is also used as a research compound in the field of organic chemistry. Its unique structure makes it an interesting subject for studying various chemical reactions and understanding the effects of fluorination on the properties and reactivity of pyrimidin-4-one derivatives.

InChI:InChI=1/C4H4FN3O/c5-2-1-7-4(6)8-3(2)9/h1H,(H3,6,7,8,9)

Upstream product

• 3013-92-1 1,3-dimethyl-5-fluorouracil 
• 50-01-1 guanidine hydrochloride 
• 113-00-8 guanidine nitrate 

Relevant academic research and scientific papers

ALKYNYL ALCOHOLS AS KINASE INHIBITORS

Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

Tautomerism of 5-fluoro-4-hydroxy-2-methoxypyrimidine. Conditions for stabilization of the zwitterionic tautomer

5-Fluoro-4-hydroxy-2-methoxypyrimidine exists in a solution as two oxo tautomers with the conjugated and isolated double bonds in the ring. The latter tautomer has a zwitterionic structure, and it dominates in water and trifluoroethanol. 5-Fluoro-4-hydroxy-2-methoxypyrimidine in acidic medium gives rise to an equilibrium mixture of two protonated forms at a ratio of about ～1:1. The zwitterionic structure of 4-hydroxypyrimidines is stabilized if the solvent is capable for specific solvation via hydrogen bonding. Pleiades Publishing, Inc., 2006.

NOVEL RING TRANSFORMATION REACTIONS AND THEIR APPLICATIONS TO THE SYNTHESES OF POTENTIAL ANTICANCER HETEROCYCLIC COMPOUNDS

Novel heterocyclic ring trasformation reactions developed recently in our laboratory are described.They include pyrimidine to pyrimidine, pyrimidine to pyridine transformations.Also discussed are novel one-step procedures for conversion of 1,3-dimethyluracil derivatives into the pyridopyrimidine system.Some applications of these novel reactions to the syntheses of compounds of biological interest are also described.

Pyrimidine to pyrimidine transformation process

There is provided a novel process for pyrimidine to pyrimidine transformations by the displacement of the 1,2,3-portion of a pyrimidine by a 1,3-ambident nucleophile. The novel process requires that the 1 and 3 nitrogens of the pyrimidine moiety be substituted. The novel process makes available, inter alia, novel uracils, simple methods of radioisotopically labeling pyrimidine nuclei, a simple and inexpensive method of preparing the important antiviral and antileukemic material pseudoisocytidine and its new active analog 2'-deoxypseudoisocytidine.