168326-89-4

Usage

Uses

Used in Organic Synthesis:
1H-Indole, 2,3-bis(bromomethyl)-1-(phenylsulfonyl)is used as a reagent in organic synthesis for the preparation of complex organic molecules. Its bromomethyl and sulfonyl groups allow it to undergo various reactions such as nucleophilic substitution and palladium-catalyzed cross-coupling reactions.
Used in Pharmaceutical Synthesis:
1H-Indole, 2,3-bis(bromomethyl)-1-(phenylsulfonyl)is used as a building block in the synthesis of pharmaceuticals. Its unique structure and functional groups make it a valuable component in the development of new drugs.
Used in Agrochemical Synthesis:
1H-Indole, 2,3-bis(bromomethyl)-1-(phenylsulfonyl)is also used in the synthesis of agrochemicals. Its versatility in undergoing different types of reactions makes it a useful component in the development of new agrochemicals.
Used in Medicinal Chemistry Research:
1H-Indole, 2,3-bis(bromomethyl)-1-(phenylsulfonyl)is used in medicinal chemistry research due to the presence of the phenylsulfonyl group, which can impart specific biological activity to the molecule. This makes it potentially useful in the discovery and development of new therapeutic agents.

Upstream product

• 116325-48-5 N-benzenesulfonyl-2,3-dimethyl-1H-indole 
• 856112-53-3 1-benzenesulfonyl-3-bromomethyl-2-methyl-1H-indole 
• 98-09-9 benzenesulfonyl chloride 

Downstream Products

• 477952-96-8 2-(p-methoxybenzyl)-4-(phenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole 
• 477952-94-6 2-i-propyl-4-(phenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole 
• 477952-93-5 2-tert-butyl-4-(phenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole 
• 477952-95-7 2-benzyl-4-(phenylsulfonyl)-1,2,3,4-tetrahydropyrrolo[3,4-b]indole 
• 1150111-73-1 1-phenylsulfonyl-2,3-bis(3,4-dimethoxybenzyl)-1H-indole 
• 1150615-61-4 C₂₈H₂₃NO₂S₃ 
• 1269632-72-5 2,3-bis[(diethoxyphosphoryl)methyl]-1-phenylsulfonyl-indole 

Relevant academic research and scientific papers

The generation of Indole-2,3-quinodimethanes from the Deamination of 1,2,3,4-Tetrahydropyrrolo[3,4-b]indoles

A novel generation of indole-2,3-quinodimethanes via the deamination of 1,2,3,4-tetrahydropyrrolo[s3,4-b]indoles is reported.

A facile synthesis of 1-phenylsulfonyl-3-substituted-2-cyanoindoles, 1-phenylsulfonyl-2-methyl-3-cyanoindoles, and bifunctional 1- phenylsulfonylindoles

A facile 'one-pot' introduction of the cyano group into the 2/3-position of indole has been developed from the corresponding aldehydes using anhydrous aluminum chloride and sodium azide. Georg Thieme Verlag Stuttgart.

A facile preparation of N-protected indolaldehydes using a modified Hass procedure

The preparation of a variety of N-protected indolaldehydes is reported via the reaction of N-protected bromomethylindoles with 2-nitropropane using NaH/DMF.

Stille carbonylation of N-protected bromomethylindoles

A variety of N-protected indolylmethylbromides are carbonylated using 5 mol % Pd(PPh3)2Cl2 under Stille conditions in the presence of an alcohol to afford the corresponding methyl/ethyl esters.

Synthesis of N-substituted pyrrolo[3,4-b]indoles from 2,3-dimethylindole

Pyrrolo[3,4-b]indoles 8 are conveniently synthesized from 2,3-dimethylindole (4) in four steps, the last of which is DDQ oxidation of dihydropyrrolo[3,4-b]indoles 7 (85-98% yield).

Unusual oxidation of 2 (or 3)-methylindole derivatives with active manganese dioxide

Oxidation of 15-methoxy-1-phenylsulfonyl-2-methyl indole-3-aldehyde (3) with active manganese dioxide to the corresponding indole-2,3-dialdehyde (4) and similar reactions are reported.