168412-89-3Relevant academic research and scientific papers
Enantioselective synthesis of salmeterol via asymmetric borane reduction
Hett, Robert,Stare, Ragnar,Helquist, Paul
, p. 9375 - 9378 (1994)
Enantioselective syntheses of both enantiomers of salmeterol are accomplished using asymmetric borane reductions with chiral oxazaborolidines as catalysts.
SUBSTITUTED PHENYLPHOSPHATES AS MUTUAL PRODRUGS OF STEROIDS AND β -AGONISTS FOR THE TREATMENT OF PULMONARY INFLAMMATION AND BRONCHOCONSTRICTION
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Page/Page column 38, (2008/06/13)
A mutual prodrug of a corticosteroid and a substituted phenylphosphate (β-agonist derivative) for formulation for delivery by aerosolization to inhibit pulmonary inflammation and bronchoconstriction is described. The mutual prodrug is preferably formulate
BENZYLPHOSPHATE AND SUBSTITUTED BENZYLPHOSPHATE PRODRUGS FOR TRE TREATMENT OF PULMONARY INFLAMMATION
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Page/Page column 51-52, (2010/02/12)
A prodrug of a corticosteroid, lidocaine or related local anesthetic composition for formulation for delivery by aerosolization to inhibit inflammation in asthmatic lungs is described. The prodrug is preferably formulated in a 5 ml solution of a quarter normal saline having pH between 5.0 and 7.0 for the treatment of respiratory tract inflammation by an aerosol having mass medium average diameter predominantly between 1 to 5 μ produced by nebulization or dry powder inhaler.
Synthesis of 1-amino-6-(4-phenylbutoxy)hexane: Arylalkylamino group in Salmeterol
Nangia, A.,Praveen, P.,Dubey, A. K.
, p. 629 - 631 (2007/10/03)
An efficient preparation of the title arylalkyl amine (7) from 4-phenylbutanol and 1,6-dibromohexane (55percent overall yield in 3 steps) is reported.
