168418-07-3Relevant articles and documents
Aminopropylation of vitamin D hormone (1α,25-dihydroxyvitamin D3), its biological precursors, and other steroidal alcohols: An anchoring moiety for affinity studies of sterols
Roy, Aloka,Ray, Rahul
, p. 600 - 603 (2007/10/03)
In this communication we describe a simple two-step procedure for the conversion of several steroidal alcohols to their aminopropyl ether derivatives.To demonstrate the usefulness of this procedure we synthesized a second-generation photoaffinity labeling analog of 1α,25-dihydroxyvitamin D3, and a 25-hydroxyvitamin D3 derivative containing a long and chemically stable tether.Utilities of these aminopropyl ether derivatives of steroids in various affinity studies of receptor proteins are discussed. (Steroids 60:530-533, 1995)