16847-90-8

Upstream product

• 34006-60-5 ethyl 2-chloro-2-ethoxyacetate 
• 603-35-0 triphenylphosphine 
• 6065-82-3 Ethyl diethoxyacetate 

Downstream Products

• 14373-86-5 (E)-2-ethoxy-3-phenylacrylic acid ethyl ester 
• 13676-12-5 (Z)-2-ethoxy-3-phenylacrylic acid ethyl ester 
• 222835-03-2 3-(4-benzyloxy-phenyl)-2-ethoxy-acrylic acid ethyl ester 
• 475481-47-1 3-(4-benzyloxy-benzo[b]thiophen-7-yl)-2(Z,E)-ethoxy-acrylic acid ethyl ester 
• 475481-78-8 3-(4-benzyloxy-benzofuran-7-yl)-2Z-ethoxy-acrylic acid ethyl ester 
• 1072031-81-2 ethyl 2-ethoxy-3-(3-formylphenyl)acrylate 
• 1072031-65-2 ethyl 2-ethoxy-3-(3-(2-methyl-1,3-dioxolan-2-yl)phenyl)acrylate 
• 1224104-14-6 (Z)-ethyl 3-(4-(benzyloxy)-3,5-difluorophenyl)-2-ethoxyacrylate 
• 475481-86-8 (rac)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester 
• 1092166-72-7 (Z)-3-(4-{3-[4-(butane-1-sulfonyloxy)-3-methoxy-phenyl]-propyl}-3-butoxy-phenyl)-2-ethoxy-ethyl acrylate 
• 1092167-44-6 (Z)-3-{3-butoxy-4-[3-(4-methoxy-phenyl)-propyl]-phenyl}-2-ethoxy-ethyl acrylate 
• 1092166-76-1 (Z)-3-(3-butoxy-4-hydroxy-phenyl)-2-ethoxy-ethyl acrylate 
• 784149-96-8 C₁₉H₂₁NO₄ 
• 343870-75-7 [rac]-2-ethoxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid ethyl ester 

Relevant academic research and scientific papers

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

ARYL GPR120 RECEPTOR AGONISTS AND USES THEREOF

Aryl GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

GPR120 RECEPTOR AGONISTS AND USES THEREOF

GPR120 agonists are provided. These compounds are useful for the treatment of metabolic diseases, including Type II diabetes and diseases associated with poor glycemic control.

NOVEL 3-PHENYL ACRYLIC ACID COMPOUND ACTIVATORS OF TYPE PPAR RECEPTORS AND PHARMACEUTICAL/COSMETIC COMPOSITIONS COMPRISED THEREOF

Novel 3-phenyl acrylic acid compounds have the following general formula (I): and are formulated into pharmaceutical compositions for administration in human or veterinary medicine (in dermatology, as well as in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or into cosmetic compositions.

1,3-Dipolar Cycloadditions of Ethoxycarbonyl-nitrile Benzylamine, and Synthesis of β-Amino Acids. Synthesis and Reactions of Ethyl 2-Chloro-2-ethoxyacetate and 2-Chloro-2-ethoxyacetyl Chloride

The principles of 1,2-cyano-hydroxylation of olefins were applied to the preparation of 1,2-cyano-amines.The dipole component of this cycloaddition was nitrile imines, which formed pyrazolines with olefins.Ring cleavage was accomplished by thermolysis of 3-carboxypyrazolines, which gave 1,2-cyano-amines and subsequent hydrolysis gave β-amino acids.The synthesis of the title reagents were described.Ethyl 2-chloro-2-ethoxy-acetate gave selectively oximes, hydrazones, nitrones, and phosphonium salts with hydroxylamine, hydrazines, N-substituted hydroxylamines and triphenylphosphine respectively.The phosphonium salt was used in a Wittig reaction with aldehydes to give α-ketoesters.Treatment of the acid chloride with allyl alcohols and subsequently with a monosubstituted hydroxylamine gave the allylic ester nitrone, which underwent intramolecular cyclization.Similarly, intramolecular cyclization were carried out with the allylic ester - nitrile oxime and allylic ester - nitrile imine systems.