34006-60-5

Basic information

• Product Name: 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER
• Synonyms: ethyl chloroethoxyacetate;Remaindermainlyethyldiethoxyacetate;2-Chloro-2-ethoxyacetic acid ethyl ester, remainder mainly ethyl diethoxyacetate, 90%;2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER 90%,REMAINDER MAINLY ETHYL DIETHOXYACETATE;2-Chloro-2-ethoxyacetic acid ethyl ester, 98 %;2-Chloro-2-ethoxyacetic acid ethyl ester, 90%, remainder mainly ethyl diethoxyacetat;Chloro(ethoxy)acetic acid ethyl ester;2-Chloro-2-Ethoxyacetic Acid Ethyl
• CAS NO: 34006-60-5
• Molecular Formula: C₆H₁₁ClO₃
• Molecular Weight: 166.6
• EINECS: 251-786-9
• Mol File: 34006-60-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 234.82°C (rough estimate)
• Flash Point: 84 °C
• Appearance: Clear colorless to orange-brown/Liquid
• Density: 1.2277 (rough estimate)
• Vapor Pressure: 0.202mmHg at 25°C
• Refractive Index: 1.4307
• Stability: Stable. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER(34006-60-5)
• EPA Substance Registry System: 2-CHLORO-2-ETHOXYACETIC ACID ETHYL ESTER(34006-60-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• Hazardous Substances Data: 34006-60-5(Hazardous Substances Data)

Usage

Chemical Properties

colourless liquid

InChI:InChI=1/C6H11ClO3/c1-3-9-5(7)6(8)10-4-2/h5H,3-4H2,1-2H3/t5-/m0/s1

Upstream product

• 75-36-5 acetyl chloride 
• 6065-82-3 Ethyl diethoxyacetate 
• 7719-09-7 thionyl chloride 
• 49653-17-0 ethyl 2-ethoxyglycolate 
• 64-17-5 ethanol 
• 10026-13-8 phosphorus pentachloride 
• 623-73-4 diazoacetic acid ethyl ester 
• 60-29-7 diethyl ether 
• 20461-86-3 2,2-diethoxy acetic acid 

Downstream Products

• 854761-05-0 (RS)-ethoxy-[3-(4-methoxy-phenyl)-pyrazol-1-yl]-acetic acid ethyl ester 
• 1224104-14-6 (Z)-ethyl 3-(4-(benzyloxy)-3,5-difluorophenyl)-2-ethoxyacrylate 
• 1344992-30-8 ethyl 2-[2-[2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-4-fluorophenoxy]phenoxy]-2-ethoxyacetate 
• 13676-12-5 (Z)-2-ethoxy-3-phenylacrylic acid ethyl ester 
• 14373-86-5 (E)-2-ethoxy-3-phenylacrylic acid ethyl ester 
• 4541-73-5 2,2-bis-(4-methoxyphenyl)acetic acid 
• 16847-90-8 (1,2-diethoxy-2-oxoethyl)triphenylphosphonium chloride 
• 22121-86-4 ethyl 2-ethoxyacrylate 
• 36141-66-9 ethyl 2-hydroxy-2-(4-methoxyphenyl)acetate 
• 14062-18-1 ethyl p-methoxyphenylacetate 
• 7153-16-4 di-O-ethyl-DL-tartaric acid diethyl ester 
• 2122-70-5 ethyl 2-(1-naphthyl)acetate 
• 18066-68-7 ethyl 3,4-dimethoxyphenylacetate 

Relevant articles and documents

NOVEL BIAROMATIC COMPOUNDS THAT MODULATE PPAR-RECEPTORS

Novel biaromatic compounds that modulate peroxisome proliferator-activator receptors, known as PPAR, having the formula (I): are formulated into pharmaceutical compositions useful in human or veterinary medicine, or alternatively, in cosmetic compositions.

NOVEL COMPOUNDS THAT MODULATE PPARγ TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS

The invention relates to novel compounds corresponding to the general formula (I) below: (I) and also to the method for preparing them, and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism),-or alternatively in cosmetic compositions.

Process development on the enantioselective enzymatic hydrolysis of S-ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate

A novel biocatalytic approach for the large-scale production of S-2-ethoxy-3-(4-hydroxyphenyl)propanoic acid S-1 from its racemic ethylester rac-2 by enantioselective hydrolysis has been developed. S-1 is an important building block in the synthesis of PPARα and -γ agonists such as Ragaglitazar [NNC 61-0029 ((-)DRF2725)]. The development history comprises enzyme screening, biocatalyst and process optimization, and scale-up to pilot plant. The project was thereby highly interdisciplinary by combining biotechnology and chemistry technologies. The final process was successfully run on a 44-kg pilot scale in 43-48% yields and with high enantiomeric purities (98.4-99.6% ee).