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Usage

Uses

Used in Pharmaceutical Synthesis:
1-[(4-Chlorophenyl)sulfonyl]-1H-pyrrole is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Cancer Research:
In the field of cancer research, 1-[(4-Chlorophenyl)sulfonyl]-1H-pyrrole is studied for its potential anti-cancer properties. It has shown promise in inhibiting the growth and proliferation of cancer cells, making it a candidate for further investigation in oncology.
Used in Anti-Inflammatory Research:
1-[(4-Chlorophenyl)sulfonyl]-1H-pyrrole is also being explored for its potential anti-inflammatory properties. Its ability to modulate inflammatory responses could lead to the development of new treatments for inflammatory diseases.
Used in Photodynamic Therapy:
As a potential photosensitizer, 1-[(4-Chlorophenyl)sulfonyl]-1H-pyrrole is being evaluated for its use in photodynamic therapy for cancer treatment. This method involves the activation of a photosensitizer by light, leading to the destruction of cancer cells while minimizing damage to surrounding healthy tissue.
Used in Chemical Research:
1-[(4-Chlorophenyl)sulfonyl]-1H-pyrrole serves as a valuable compound in chemical research, providing insights into the properties and reactions of pyrrole derivatives. Its study contributes to the broader understanding of organic chemistry and the development of new synthetic methods and applications.

InChI:InChI=1/C10H8ClNO2S/c11-9-3-5-10(6-4-9)15(13,14)12-7-1-2-8-12/h1-8H

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 109-97-7 pyrrole 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 1309439-43-7 N-(4-((1H-pyrrol-1-yl)sulfonyl)phenyl)-N'-phenylurea 
• 98-57-7 4-chlorophenyl methyl sulfone 

Relevant academic research and scientific papers

Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light

Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.

Synthesis of N -Sulfonyl- and N -Acylpyrroles via a Ring-Closing Metathesis/Dehydrogenation Tandem Reaction

N -Sulfonyl- and N -acylpyrroles were synthesized via olefin ring-closing metathesis of diallylamines and in situ oxidative aromatization in the presence of the ruthenium Grubbs catalyst and a suitable copper catalyst. In the presence of Cu(OTf) 2/s

A microwave-assisted, green procedure for the synthesis of N-aryl sulfonyl and N-aryl pyrroles

A simplified approach to the uncatalyzed Paal-Knorr condensation using microwave irradiation in water is described.

Iron-catalyzed inexpensive and practical synthesis of N-substituted pyrroles in water

An operationally simple, practical, and economical protocol for iron(III) chloride catalyzed Paal-Knorr pyrrole synthesis in water in good to excellent yields has been developed. Several N-substituted pyrroles are readily prepared from the reaction of 2,5-dimethoxytetrahydrofuran and aryl/alkyl, sulfonyl and acyl amines under very mild reaction conditions. Georg Thieme Verlag Stuttgart.

Triflic acid controlled successive annelation of aromatic sulfonamides: an efficient one-pot synthesis of N-sulfonyl pyrroles, indoles and carbazoles

A novel one-pot synthesis of N-substituted heterocycles via successive cyclization/annelation starting from primary sulfonamides is described. This process directly leads to N-sulfonyl pyrroles, indoles and carbazoles. The selection of an appropriate reac

1-arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles, a novel class of anti-HIV-1 reverse transcriptase inhibitors

Various 1-arylsulfonyl-3-(α-hydroxybenzyl)-1H-pyrroles were prepared by Friedel-Crafts reaction of 1-arylsulfonyl-1H-pyrroles with aroylchlorides in the presence of aluminum trichloride, followed by reduction of the ketones to the required carbinols. The compounds were identified as a novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors characterized by the presence of a diarylcarbinol moiety, a chemical feature that strictly correlates with the anti-HIV-1 activity.

A facile synthesis of N-substituted pyrroles

Phosphorous pentoxide is the catalyst of choice for the facile conversion of primary amines, aromatic amines, sulfonamides and primary amides into the corresponding N-substituted pyrroles from 2,5-dimethoxytetrahydrofuran.