16851-83-5

Basic information

• Product Name: 1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLE
• Synonyms: BUTTPARK 97\57-35;1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLE;1-[(4-chlorophenyl)sulphonyl]-1H-pyrrole;N-(4-CHLOROBENZENESULFONYL)PYRROLE
• CAS NO: 16851-83-5
• Molecular Formula: C₁₀H₈ClNO₂S
• Molecular Weight: 241.69
• Mol File: 16851-83-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 116℃
• Boiling Point: 393.6°Cat760mmHg
• Flash Point: 191.9°C
• Appearance: /
• Density: 1.36g/cm³
• Vapor Pressure: 2.1E-06mmHg at 25°C
• Refractive Index: 1.616
• PKA: -8.94±0.70(Predicted)
• CAS DataBase Reference: 1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLE(16851-83-5)
• EPA Substance Registry System: 1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLE(16851-83-5)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S37/39:Wear suitable g
• Hazardous Substances Data: 16851-83-5(Hazardous Substances Data)

Usage

General Description

1-[(4-Chlorophenyl)sulfonyl]-1H-pyrrole is a chemical compound with the molecular formula C11H8ClNO2S. It is a pyrrole derivative with a sulfonyl group and a chlorophenyl group attached to the pyrrole ring. 1-[(4-CHLOROPHENYL)SULFONYL]-1H-PYRROLE is used in the synthesis of pharmaceuticals and organic compounds. It has also been studied for its potential biological activities, such as anti-cancer and anti-inflammatory properties. Additionally, it has been evaluated for its potential as a photosensitizer in photodynamic therapy for cancer treatment. However, further research is needed to fully understand its potential applications and effects.

InChI:InChI=1/C10H8ClNO2S/c11-9-3-5-10(6-4-9)15(13,14)12-7-1-2-8-12/h1-8H

Upstream product

• 696-59-3 cis,trans-2,5-dimethoxytetrahydrofuran 
• 98-64-6 4-Chlorobenzenesulfonamide 
• 109-97-7 pyrrole 
• 98-60-2 4-chlorobenzenesulfonyl chloride 

Downstream Products

• 98-57-7 4-chlorophenyl methyl sulfone 
• 1309439-43-7 N-(4-((1H-pyrrol-1-yl)sulfonyl)phenyl)-N'-phenylurea 

Relevant articles and documents

Primary Sulfonamide Functionalization via Sulfonyl Pyrroles: Seeing the N?Ts Bond in a Different Light

Despite common occurrence in molecules of value, methods for transforming sulfonamides are distinctly lacking. Here we introduce easy-to-access sulfonyl pyrroles as synthetic linchpins for sulfonamide functionalization. The versatility of the sulfonyl pyrrole unit is shown by generating a variety of products through chemical, electrochemical and photochemical pathways. Preliminary results on the direct functionalization of primary sulfonamides are also provided, which may lead to new modes of activation.

A microwave-assisted, green procedure for the synthesis of N-aryl sulfonyl and N-aryl pyrroles

A simplified approach to the uncatalyzed Paal-Knorr condensation using microwave irradiation in water is described.

Triflic acid controlled successive annelation of aromatic sulfonamides: an efficient one-pot synthesis of N-sulfonyl pyrroles, indoles and carbazoles

A novel one-pot synthesis of N-substituted heterocycles via successive cyclization/annelation starting from primary sulfonamides is described. This process directly leads to N-sulfonyl pyrroles, indoles and carbazoles. The selection of an appropriate reac