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Usage

Uses

Used in Chemical Synthesis:
4-Methylsulfuryl chlorobenzene is used as a key intermediate in the synthesis of various organic compounds, including pharmaceuticals and agrochemicals. Its reactivity and functional groups make it a versatile building block for creating a wide range of products.
Used in Analytical Chemistry:
In the field of analytical chemistry, 4-methylsulfuryl chlorobenzene serves as a standard reference material for the quantification of 4-chlorophenyl methyl sulfide by high-performance liquid chromatography (HPLC) in rat liver microsomes. This application is crucial for accurately determining the concentration of target compounds in biological samples, which can be used to assess their toxicity and metabolic pathways.
Used in the Preparation of 4-(Methylsulfonyl)aniline:
4-Methylsulfuryl chlorobenzene is utilized in the preparation of 4-(methylsulfonyl)aniline by reacting with ammonia. This reaction is an important step in the synthesis of various aniline derivatives, which have applications in the production of dyes, pigments, and pharmaceuticals.

InChI:InChI=1/C14H12Cl2O2S/c15-13-5-1-11(2-6-13)9-19(17,18)10-12-3-7-14(16)8-4-12/h1-8H,9-10H2

Upstream product

• 123-09-1 4-chlorophenyl methyl sulfide 
• 124-63-0 methanesulfonyl chloride 
• 108-90-7 chlorobenzene 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 79-11-8 chloroacetic acid 
• 934-73-6 methyl 4-chlorophenyl sulfoxide 
• 30541-56-1 adamantylidene-adamantane 
• 3405-89-8 2-(4-chloro-phenylsulfonyl)acetic acid 
• 66-27-3 Methyl methanesulfonate 
• 558-25-8 methyl fluorosulfonate 
• 7143-01-3 Methanesulfonic anhydride 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 150221-20-8 1-(4-(methylsulfonyl)phenyl)piperidine 
• 63029-15-2 (4-(methylsulfonyl)phenyl)(phenyl)sulfane 
• 33599-22-3 (4-methanesulfonylphenyl)-N,N-dimethyl-amine 
• 58940-96-8 Aethoxy-oxalyl-methyl-p-chlorphenyl-sulfon 
• 19760-89-5 p-Propoxy-phenylmethylsulfon 
• 19760-88-4 4-Ethoxyphenyl methyl sulphone 
• 19760-87-3 p-Amyloxy-phenylmethylsulfon 
• 727-26-4 [(4-chlorophenyl)sulfonyl][(trifluoromethyl)sulfonyl]methane 
• 877-66-7 4-(methylsulfonyl)phenylhydrazine 
• 100716-73-2 4-chlorophenyl 2-phenylethyl sulphone 
• 108715-37-3 4-(4-methanesulfonyl-phenylsulfanyl)-N,N-dimethyl-aniline 
• 108715-79-3 3-(4-methanesulfonyl-phenylsulfanyl)-N,N-dimethyl-aniline 
• 105903-18-2 3-(4-methanesulfonyl-phenylsulfanyl)-aniline 
• 54458-14-9 4-(4-methanesulfonyl-phenylsulfanyl)-aniline 

Relevant academic research and scientific papers

Crystal and molecular structure of methyl-(4-chlorophenyl)sulfone

Sulfones are known to be biologically active compounds. X-ray diffraction is used to determine the crystal and molecular structure of methyl-(4-chlorophenyl)sulfone. The closest molecules are in pairs oriented to each other by their chlorine atoms. The cr

High Chemoselectivity in the Construction of Aryl Methyl Sulfones via an Unexpected C-S Bond Formation between Sulfonylhydrazides and Dimethyl Phosphite

A highly chemoselective route to aryl methyl sulfones via an unexpected C S bond formation between sulfonylhydrazides and dimethyl phosphite catalyzed by NaI under mild conditions has been established. This transformation provides an alternative and metal-free pathway to acquire various aryl methyl sulfones in good to excellent yields. Notably, dimethyl phosphite was employed as a stable and readily available alkyl source.

Method for synthesizing aryl alkyl sulfone compound by promoting oxidation of aryl alkyl thioether compound through visible light

The invention discloses a method for synthesizing an aryl alkyl sulfone compound by promoting oxidation of an aryl alkyl thioether compound through visible light. The method comprises the following steps of: performing one-pot reaction on an aryl alkyl thioether compound and sodium trifluoromethanesulfinate in a diethylene glycol dibutyl ether solution system under the conditions of oxygen-containing atmosphere and 385-390 nm purple light irradiation to generate the aryl alkyl sulfone compound. The method has the advantages of mild conditions, simple operation, environmental protection, easilyavailable raw materials, excellent compatibility of substrate functional groups, high reaction yield and the like.

Polyoxometalate-Based Organic-Inorganic Hybrids as Heterogeneous Catalysts for Cycloaddition of CO2with Epoxides and Oxidative Desulfurization Reactions

Self-assembly of polyoxometalates, transition metal salts, and 2,6-bis(2′-pyridyl)-4-hydroxypyridine (LOH) obtained four organic-inorganic hybrids [Co2.5(LOH)(LO)2(H2O)2(PW12O39)]·3CH3CN·2OH (1), [Zn1.5(LOH)3]·(PMo12O40)·CH3OH·2H2O (2), [Cd1.5(LOH)3]·(PW12O40)·2CH3OH·1.5H2O (3), and [Mn(LOH)2]·(PW12O40)·2CH3CN·H3O (4). Hybrid 1 exhibits an extended chain, which could be further connected into a 3D supramolecular architecture by H-bonds. Hybrids 2-4 feature monomolecular structures, which are further bridged via H-bonds to yield charming 3D supramolecular structures. Noteworthy, 1 and 2 can be employed as recyclable and highly efficient heterogeneous catalysts. The activated 1 displays a high catalytic activity for the cycloaddition reaction of CO2 and epoxides. Hybrid 2 exhibits an excellent catalytic performance for the oxidative desulfurization reaction.

Synthesis of a light-harvesting ruthenium porphyrin complex substituted with BODIPY units. Implications for visible light-promoted catalytic oxidations

A light-harvesting ruthenium porphyrin substituted covalently with four boron-dipyrrin (BODIPY) moieties has been synthesized and studied. The resulting complex showed an efficient decarbonylation reaction predominantly due to a photo-induced energy transfer process. Chemical oxidation of the ruthenium(ii) BODIPY-porphyrin afforded a high-energytrans-dioxoruthenium(vi) species that is one order of magnitude more reactive towards alkene oxidation than those analogues supported by conventional porphyrins. In the presence of visible light, the ruthenium(ii) BODIPY-porphyrin displayed remarkable catalytic activity toward sulfide oxidation and alkene epoxidation using iodobenzene diacetate [PhI(OAc)2] and 2,6-dichloropyridineN-oxide (Cl2pyNO) as terminal oxidants, respectively. The findings in this work highlight that porphyrin-BODIPY conjugated metal complexes are potentially useful for visible light-promoted catalytic oxidations.

Assembly of polyoxometalate-thiacalix[4]arene-based inorganic-organic hybrids as efficient catalytic oxidation desulfurization catalysts

Self-assembly of polyoxometalates, Ni(ii)/Ag(i) cations and tetra-[5-(mercapto)-1-methyltetrazole]-thiacalix[4]arene (L) yielded three inorganic-organic hybrids, namely, [Ni3L2(CH3OH)6(H2O)4][PMo12O40]2·3CH3OH·2H2O (1), [Ni3L2(CH3OH)6(H2O)4][PW12O40]2·3CH3OH·2H2O (2) and [Ag3L(PMo12O40)] (3). In hybrids (1) and (2), Ni(ii) cations are linked by L ligands to produce layered frameworks, and H bonds among the [PMo12O40]3?/[PW12O40]3?anions and L ligands lengthen the structures to form 3D supramolecular architectures. Hybrid (3) exhibits a 3D architecture, of which Ag(i) cations not only coordinated with the N and O atoms of L ligands and [PMo12O40]3?anions simultaneously, but also connected each other by Ag-Ag interactions. It is worth mentioning that1and3as recyclable catalysts show excellent heterogeneous catalytic activity in oxidation desulfurization reactions.

Air atmospheric photocatalytic oxidation by ultrathin C,N-TiO2nanosheets

Herein, we demonstrate the highly efficient photocatalytic sulfide oxidation reaction under mild conditions,i.e.in air, at room temperature and in the absence of a sacrificial reagent, co-catalyst or redox mediator, by using ultrathin C,N-TiO2nanosheets as a photocatalyst.

COVALENT ORGANIC FRAMEWORKS AND APPLICATIONS AS PHOTOCATALYSTS

Described herein are covalent organic frameworks. The covalent organic frameworks have unique structural and physical properties, which lends them to be versatile in a number of different applications and uses. In one aspect, the covalent organic frameworks are composed of a plurality of fused aromatic groups and electron-deficient chromophores. The covalent organic frameworks are useful as photocatalysts in a number of different applications.

A sustainable approach towards solventless organic oxidations catalyzed by polymer immobilized Nb(V)-peroxido compounds with H2O2 as oxidant

New heterogeneous catalysts comprising of peroxidoniobium(V) complexes immobilized on amino acid grafted cross-linked poly(styrene-divinylbenzene) resin has been developed. Results of FTIR, Raman, NMR, XPS, XRD, EDX, SEM, BET, TGA, and elemental analysis confirmed the successful anchoring of triperoxidoniobium(V), [Nb(O2)3]? species to the host polymer via the pendant amino acid groups. The supported catalysts exhibited excellent performance in epoxidation of styrene and a range of cyclic and terpenic compounds under environmentally acceptable solvent-free condition, with aqueous H2O2 as oxidant. The catalytic protocols provided excellent conversion to the desired epoxide (up to 100%) with selectivity > 99%, TON as high as 1000, and high H2O2 utilization efficiency (92–97%). Moreover, the catalysts efficiently facilitated chemoselective solvent-free oxidation of a variety of thioethers to sulfones at room temperature. Simple operational strategy, easy recyclability for multiple reaction cycles with the consistent activity-selectivity profile are the additional significant attributes of the developed catalytic processes.

Method for catalytically oxidizing thioether to sulphone

The invention discloses a method for catalytically oxidizing thioether to sulphone. In this method, thioether is added to an ethanol solution. H2 O2 The nitrogen-nitrogen co-doped graphene catalyst is reacted at room temperature to obtain sulfone. The method is simple and convenient to operate, environment-friendly in reaction process, low in production cost, free of metal catalysts, free of secondary pollution, mild in reaction conditions, low in catalyst consumption, high and product yield and the like.