168632-98-2

Upstream product

• 100-46-9 benzylamine 
• 59830-60-3 N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde 

Downstream Products

• 243462-36-4 Y-40018 
• 1027180-05-7 {1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-methyl]-6-oxo-2-pyridin-3-yl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 1026417-77-5 {1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-methyl]-6-oxo-2-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 1027827-18-4 {1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-methyl]-6-oxo-2-pyridin-4-yl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 1026395-17-4 {1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-methyl]-6-oxo-2-phenyl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 1026583-79-8 {1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-methyl]-6-oxo-2-phenyl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 1026878-63-6 [1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-methyl]-2-(3-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester 
• 1027248-69-6 [1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-methyl]-2-(3-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester 
• 243462-51-3 2-[5-benzyloxycarbonylamino-2-(3-chlorophenyl)-1,6-dihydro-6-oxo-1-pyrimidinyl]-N-[1-benzyl-3-[N-(benzyl)carbamoyl]-3,3-difluoro-2-hydroxypropyl]acetamide 
• 243462-52-4 2-[5-benzyloxycarbonylamino-2-(3-chlorophenyl)-1,6-dihydro-6-oxo-1-pyrimidinyl]-N-[1-benzyl-3-[N-(benzyl)carbamoyl]-3,3-difluoro-2-oxopropyl]acetamide 
• 1026599-48-3 {1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-methyl]-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 1026057-61-3 {1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-hydroxy-propylcarbamoyl)-methyl]-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl}-carbamic acid benzyl ester 
• 184709-55-5 [1-[(1-benzyl-3-benzylcarbamoyl-3,3-difluoro-2-oxo-propylcarbamoyl)-methyl]-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid benzyl ester 

Relevant academic research and scientific papers

Synthesis, structure - Activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase

Potent human chymase inhibitors with high enzymatic selectivity and satisfactory metabolic stability were obtained by replacing the Val-Pro (P3-P2) dipeptide portion of the previously described inhibitor 1 with a nonpeptidic pyrimidi

Inhibitors of β-amyloid protein production

This invention relates to compounds and pharmaceutical compositions, and methods for inhibiting or preventing the amyloid protein deposits in the brain which are associated with Alzheimer's disease and aged Down's syndrome patients. More particularly, it relates to the treatment of Alzheimer's disease.