243462-52-4Relevant academic research and scientific papers
IgE antibody production inhibitors and autoimmune diseases inhibitors
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, (2008/06/13)
The present invention relates to an IgE antibody production inhibitor and an autoimmune disease suppressant containing a heterocyclic amide compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof as an activ
Synthesis, structure - Activity relationships, and pharmacokinetic profiles of nonpeptidic difluoromethylene ketones as novel inhibitors of human chymase
Akahoshi,Ashimori,Sakashita,Yoshimura,Eda,Imada,Nakajima,Mitsutomi,Kuwahara,Ohtsuka,Fukaya,Miyazaki,Nakamura
, p. 1297 - 1304 (2007/10/03)
Potent human chymase inhibitors with high enzymatic selectivity and satisfactory metabolic stability were obtained by replacing the Val-Pro (P3-P2) dipeptide portion of the previously described inhibitor 1 with a nonpeptidic pyrimidi
