1688-19-3

Upstream product

• 1195-09-1 5-methyl-2-methoxyphenol 
• 108-24-7 acetic anhydride 
• 104-93-8 p-methylanizole 
• 127-09-3 sodium acetate 
• 64-19-7 acetic acid 

Downstream Products

• 162853-20-5 1-(4-hydroxy-5-methoxy-2-methyl-phenyl)-ethanone 
• 1195-09-1 5-methyl-2-methoxyphenol 
• 4223-86-3 1-<2-Hydroxy-3-methoxy-6-methyl-phenyl>-aethan-1-on 
• 857831-73-3 4-ethyl-2-bromo-6-methoxy-3-methyl-phenol 
• 91345-81-2 1-ethyl-3-bromo-4,5-dimethoxy-2-methyl-benzene 
• 120550-71-2 4-ethyl-2-methoxy-5-methylphenol 
• 89791-96-8 5-methyl-3-nitrobenzene-1,2-diol 

Relevant academic research and scientific papers

Direct Acetoxylation of Arenes

Acetoxylation of arenes is an important reaction and an unmet need in chemistry. We report a metal-free, direct acetoxylation reaction using sodium nitrate under an anhydrous environment of trifluoroacetic acid, acetic acid, and acetic anhydride. Arenes (31 examples), with oxidation potentials (Eox, in V vs SCE) lower than benzene (2.48 V), were acetoxylated with good yields and regioselectivity. A stepwise, single electron-transfer mechanism is proposed.

Electron Transfer Reactions in Organic Chemistry. VII. Oxidative Acetoxylation of Aromatic Compounds by Tungsten Hexachloride

Tungsten hexachloride, a high-potential oxidant, causes fast oxidative acetoxylation of ring and/or α positions of aromatic compounds, even as difficalty oxidizable ones as mesitylene and p-xylene.Chlorination is a completing reaction which cannnot be completely suppressed.The acetoxylation process in all likelihood proceeds via an electron transfer mechanism, involving initial formation of the radical cation of the substrate.