16885-94-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
1-Propyl-1H-indole is used as a building block in the synthesis of various pharmaceutical drugs and agrochemicals. Its unique chemical structure allows it to be incorporated into a wide range of molecules, enhancing their therapeutic or pesticidal properties.
Used in Flavor and Fragrance Industry:
1-Propyl-1H-indole is used as a flavor and fragrance ingredient due to its distinct musky and floral odor. It can be incorporated into perfumes, cosmetics, and other scented products to provide a pleasant and long-lasting aroma.
Used in Medicinal Chemistry Research:
1-Propyl-1H-indole has been studied for its potential anti-inflammatory and anticancer properties. Its ability to modulate biological pathways involved in inflammation and cancer makes it a promising candidate for the development of new therapeutic agents.

Upstream product

• 17529-69-0 1-Propionyl-1H-indole-2,3-dione 
• 102-71-6 triethanolamine 
• 622-80-0 N-propylaniline 
• 120-72-9 indole 
• 71-23-8 propan-1-ol 
• 496-15-1 1-indoline 
• 107-08-4 1-iodo-propane 
• 125334-52-3 1-(3-bromopropyl)-1H-indole 
• 91-56-5 indole-2,3-dione 
• 107-21-1 ethylene glycol 
• 133834-92-1 1-(3-Iodopropyl)-1H-indole 
• 106-94-5 propyl bromide 
• 187737-37-7 propene 

Downstream Products

• 824959-87-7 (1-propyl-1H-indol-3-yl)(4-propyl-1-naphthalenyl)methanone 
• 42951-50-8 1-n-propyl-2-phenylindole 
• 119491-08-6 1-(1-propyl)-1H-indole-3-carbaldehyde 
• 943118-07-8 1-(1-propyl-1H-indol-3-yl) ethanone 

Relevant academic research and scientific papers

Reduction of N-Acylsatins with Complex

N-acylsatins can be directly converted in high yields to N-alkylindoles by reduction, at room temperature, with freshly prepared BH3*THF complex.This reduction represents an alternative method for the preparation of N-alkylindoles with long-chain alkyl groups, especially those with halogens within the carbon chain.

Cesium carbonate promoted N-alkylation of indoles

The N-alkylation of indoles with alkyl halides and epoxides, using cesium carbonate as the base in DMPU, is reported.

Identification of an indol-based derivative as potent and selective varicella zoster virus (VZV) inhibitor

We report the synthesis and antiviral activity of a new family of non-nucleoside antivirals, derived from the indole nucleus. Modifications of this template through Mannich and Friedel-Crafts reactions, coupled with nucleophilic displacement and reductive

Straightforward access to novel indolo[2,3-: B] indoles via aerobic copper-catalyzed [3+2] annulation of diarylamines and indoles

Herein, we report an unprecedented aerobic copper-catalyzed [3+2] annulation reaction of diarylamines with indoles, which allows direct access to novel 2-diarylaminoindolo[2,3-b]indoles, a class of potential photoelectric device molecules. The developed transformation proceeds with broad substrate scope, good functional group tolerance, high chemo-selectivity, and no need for pre-preparation of specific agents, which offers a practical route for diverse and atom-economic synthesis of the desired products that are difficult to prepare with the conventional approaches.

γ-Carboline synthesis enabled by Rh(iii)-catalysed regioselective C-H annulation

A redox-neutral Rh(iii)-catalyzed C-H annulation of indolyl oximes was developed. Relying on the use of various alkynyl silanes as the terminal alkyne surrogates, the reaction exhibited a reverse regioselectivity, thus giving an exclusive and easy way for the synthesis of a wide range of substituent free γ-carbolines at C3 position with high efficiency. Deuterium-labelling experiments and kinetic analysis have preliminarily shed light on the working mode of this catalytic system. This journal is

Cobalt-Catalyzed Regioselective Direct C-4 Alkenylation of 3-Acetylindole with Michael Acceptors Using a Weakly Coordinating Functional Group

Herein, we disclosed the first report on the selective C(4)-H functionalization of 3-acetylindole derivatives using first-row transition metal cobalt where an acetyl group is acting as a weakly coordinating directing group. Selective C(4)-H functionalization has been achieved using diverse Michael acceptors (acrylate and maleimide) simply by switching the additive from copper acetate to silver carbonate. Further the formation of a cobaltacycle intermediate was also detected through HRMS for mechanistic insight.

Divergent dehydrogenative coupling of indolines with alcohols

The dehydrogenative coupling of indolines with alcohols catalyzed by an iridium complex has been achieved to afford both N- and C3-alkylated indoles selectively, by simply changing the addition time of a base additive. The iridacycle catalyst plays multiple roles in these reactions, which dehydrogenates both amines and alcohols and catalyzes the coupling reactions. Mechanistic studies reveal that a borrowing hydrogen-dehydrogenation process and a dehydrogenationborrowing hydrogen process are involved in N-alkylation and C3-alkylation reactions, respectively. The C3-alkylation reaction involves the direct coupling of two sp3 carbon centers.

Introducing tetramethylurea as a new methylene precursor: a microwave-assisted RuCl3-catalyzed cross dehydrogenative coupling approach to bis(indolyl)methanes

Herein we report a microwave assisted Ru(iii)/TBHP-mediated reaction of indoles with tetramethylurea (TMU) synthesizing symmetrical as well as unsymmetrical bis(indolyl)methanes, where TMU acts as a methylenating agent. This is the first report where TMU is used as a methylene source. Moreover, the synthesis of unsymmetrical bis(indolyl)methanes by using a carbon precursor is also reported herein for the first time. Various substituted indoles are used for the reaction. The reaction is high yielding and takes a much shorter time to accomplish compared to the existing methods.

Gold-catalyzed oxidative couplings of two indoles with one aryldiazo cyanide under oxidant-free conditions

Gold-catalyzed oxidative couplings of two indoles and one α-cyano gold carbene to form bis(indolyl)methane derivatives are described. Two different indoles are compatible with these reactions to provide reasonable yields. A plausible mechanism is postulated to rationalize the experimental data including product distributions, D2O labeling, and the significant effects of gold catalysts and cyano groups.

OPTICALLY ISOTROPIC LIQUID CRYSTAL MEDIUM AND OPTICAL DEVICE

A liquid crystal composition is described, containing an achiral component T and a chiral dopant and exhibiting an optically isotropic liquid crystal phase. The achiral component T contains at least one compound represented by formula (1). In formula (1),