168969-77-5

Upstream product

• 168608-39-7 (3S,4S,5R)-5-(((tert-butyldiphenylsilyl)oxy)methyl)tetrahydrofuran-2,3,4-triol 
• 1220093-26-4 5-O-t-butyldiphenylsilyl-3-O-(imidazolylthiocarbonyl)-1,2-O-isopropylidene-β-D-threo-pentofuranose 
• 28697-53-2 D-arabinopyranose 
• 114738-04-4 (3aS,5R,6R,6aS)-5-(((tert-butyldiphenylsilyl)oxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-6-ol 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 172751-32-5 5-O-(tert-butyldiphenylsilyl)-1,2-O-isopropylidene-β-D-threo-pentofuranose-3-ulose 
• 133048-89-2 5-O-tert-butyldiphenylsilyl-1,2-O-isopropylidene-β-D-lyxofuranose 
• 133074-84-7 Trifluoro-methanesulfonic acid (3aS,5R,6S,6aS)-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yl ester 
• 608-45-7 α-D-arabinopyranose 

Downstream Products

• 1395498-27-7 3-deoxy-1,2-O-isopropylidene-5-O-p-toluenesulfonyl-β-D-threo-pentofuranose 
• 22248-92-6 [(3aS,5S,6aS)-2,2-dimethyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-5-yl]methyl benzoate 

Relevant academic research and scientific papers

NOVEL 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Deoxygenation at the C3 position of d- and l-arabinofuranose: Stereospecific access to enantiomeric cordycepose derivatives

Efficient synthesis of 3-deoxy-1,2-O-isopropylidene-β-d- and β-l-threo-pentofuranose (1,2-O-isopropylidene-β-d- and β-l-cordycepose) was accomplished starting from d- and l-arabinofuranose derivatives, respectively, by the action of LiBH(Et)3 on corresponding intermediate 3-O-lyxofuranosyl trifluoromethanesulfonates.

Synthesis of 3-Deoxy-d-threopentofuranose 5-phosphate, a substrate of arabinose 5-phosphate isomerase

3-Deoxy-d-threopentofuranose 5-phosphate, a substrate of arabinose 5-phosphate isomerase, has been synthesised starting from d-arabinose. Selective protection of the hydroxyl groups at C-1, C-2, and C-5 allowed deoxygenation of position 3 by conversion into a thiocarbamate and radical reduction. Deprotection and phosphorylation of the primary hydroxyl group and final deprotection of the other hydroxyl groups afforded the desired compound.